癌症是现代世界中最具影响力的疾病之一，主要是因为它具有致命的后果。在这种情况下，最根本的担忧可能源于患者的延迟诊断。因此，检测各种形式的癌症势在必行。癌症研究中的一个巨大挑战是这种疾病的诊断和治疗。早期癌症诊断至关重要，因为它显着影响后续的治疗步骤。尽管做出了大量的科学努力，准确、快速地诊断癌症仍然是一项艰巨的挑战。众所周知，癌症诊断领域有效地包括了电化学方法。将适体、抗体或核酸等生物传感成分的卓越选择性与电化学传感器系统相结合已显示出积极的成果。在这项研究中，我们采用了一种新型电化学生物传感器来检测癌症。该生物传感器基于玻碳电极，采用还原氧化石墨烯/Fe3O4/Nafion/聚苯胺的纳米复合材料。我们使用 SEM、TEM、FTIR、RAMAN、VSM 和电化学方法阐明了改性过程。为了优化实验条件并监测固定过程，采用了 CV、EIS 和 SWV 等电化学技术。校准图的线性范围为 102-106 个细胞 mL-1，检测限为 5 个细胞 mL-1。© 2024。作者。

Cancer stands as one of the most impactful illnesses in the modern world, primarily owing to its lethal consequences. The fundamental concern in this context likely stems from delayed diagnoses in patients. Hence, detecting various forms of cancer is imperative. A formidable challenge in cancer research has been the diagnosis and treatment of this disease. Early cancer diagnosis is crucial, as it significantly influences subsequent therapeutic steps. Despite substantial scientific efforts, accurately and swiftly diagnosing cancer remains a formidable challenge. It is well known that the field of cancer diagnosis has effectively included electrochemical approaches. Combining the remarkable selectivity of biosensing components-such as aptamers, antibodies, or nucleic acids-with electrochemical sensor systems has shown positive outcomes. In this study, we adapt a novel electrochemical biosensor for cancer detection. This biosensor, based on a glassy carbon electrode, incorporates a nanocomposite of reduced graphene oxide/Fe3O4/Nafion/polyaniline. We elucidated the modification process using SEM, TEM, FTIR, RAMAN, VSM, and electrochemical methods. To optimize the experimental conditions and monitor the immobilization processes, electrochemical techniques such as CV, EIS, and SWV were employed. The calibration graph has a linear range of 102-106 cells mL-1, with a detection limit of 5 cells mL-1.© 2024. The Author(s).