N6-甲基腺苷 (m6A) 是真核生物中最常见的 RNA 修饰形式，在调节 RNA 稳定性、翻译和转录等各种生物过程中至关重要。 YT521-B 同源 (YTH) 基因家族中的所有成员都被归类为 m6A 阅读蛋白，能够识别和结合 RNA 上的 m6A 修饰，从而调节 RNA 代谢和跨不同生理过程的功能。 YTH 结构域包含 2 (YTHDC2) 被确定为 YTH 家族的最新成员，最近才开始因其生物学功能而出现。大量研究强调了 YTHDC2 在人类生理学中的重要性，强调了它在肿瘤进展和非肿瘤疾病中的参与。因此，本综述旨在通过总结 YTHDC2 在肿瘤和其他疾病中的功能和作用，特别关注其下游分子靶点和信号通路，进一步阐明 YTHDC2 的病理机制。© 2024。作者。

N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating RNA stability, translation, and transcription. All members within the YT521-B homology (YTH) gene family are categorized as m6A reading proteins, capable of identifying and binding m6A modifications on RNA, thereby regulating RNA metabolism and functioning across diverse physiological processes. YTH domain-containing 2 (YTHDC2), identified as the latest member of the YTH family, has only recently started to emerge for its biological function. Numerous studies have underscored the significance of YTHDC2 in human physiology, highlighting its involvement in both tumor progression and non-tumor diseases. Consequently, this review aims to further elucidate the pathological mechanisms of YTHDC2 by summarizing its functions and roles in tumors and other diseases, with a particular focus on its downstream molecular targets and signaling pathways.© 2024. The Author(s).