癌症检测的强化筛查方案提高了头颈癌 (HNC) 患者的生存率，这凸显了解决治疗引起的心血管并发症后遗症的必要性。本研究旨在使用基于人群的综合队列数据集评估未接受放疗或化疗的 HNC 患者急性心肌梗死 (AMI) 的发病率和风险。使用倾向评分方法对总共 2976 名未患有癌症的个体和 744 名患有 HNC 的个体进行了匹配。研究结果表明，HNC 组 (2.19) 和非癌症组 (2.39) 的 AMI 发生率相当。 Cox 回归分析并未显示 HNC 患者发生 AMI 的风险显着增加（风险比：0.93，95% 置信区间：0.50-1.73）。无论 HNC 诊断后的时间如何，与非癌症组相比，HNC 组的 AMI 风险均未增加。亚组分析显示，考虑到性别、年龄、合并症和癌症类型，各组之间的 AMI 风险没有显着差异。这项研究表明，与未患癌症的个体相比，未接受放疗或化疗的 HNC 患者的 AMI 发病率或风险并未增加。

Enhanced screening protocols for cancer detection have increased survival in patients with head and neck cancer (HNC), which highlights the need to address the sequelae of therapy-induced cardiovascular complications. This study was conducted to assess the incidence and risk of acute myocardial infarction (AMI) in patients with HNC who have not undergone radiation or chemotherapy using a comprehensive, population-based cohort dataset. A total of 2976 individuals without cancer and 744 individuals with HNC were matched using the propensity score method. The findings indicated that the occurrence rates of AMI were comparable between the HNC (2.19) and non-cancer groups (2.39). Cox regression analysis did not demonstrate a significant increase in the risk of AMI in patients with HNC (hazard ratio: 0.93, 95% confidence interval: 0.50-1.73). No increased risk of AMI was observed in the HNC group compared to the non-cancer group, regardless of the time since the HNC diagnosis. Subgroup analyses showed no notable differences in the AMI risk between the groups when considering sex, age, comorbidities, and cancer type. This study showed that patients with HNC who have not been treated with radiation or chemotherapy did not exhibit an increased incidence or risk of AMI compared to individuals without cancer.