本文提出了一种基于共振光学隧道效应（ROTE）的生物传感器，用于检测癌胚抗原（CEA）。在此设计中，传感是通过倏逝波与固定在传感器表面的 CEA 的相互作用来完成的。当 CEA 与抗 CEA 结合时，它会改变传感器表面的有效折射率 (RI)，导致波长发生变化。这种转变可以通过同一模式下 FP 腔和 ROTE 腔的级联耦合来识别。实验结果进一步表明，共振波长的偏移随着CEA浓度的增加而增加。该生物传感器对 1 至 5 ng/mL 的 CEA 浓度呈线性响应，检测限 (LOD) 为 0.5 ng/mL，总 Q 因子为 9500。这项研究引入了一种识别生物分子和癌症生物标志物的新途径，对于早期癌症检测至关重要。

This paper presents a biosensor based on the resonant optical tunneling effect (ROTE) for detecting a carcinoembryonic antigen (CEA). In this design, sensing is accomplished through the interaction of the evanescent wave with the CEA immobilized on the sensor's surface. When CEA binds to the anti-CEA, it alters the effective refractive index (RI) on the sensor's surface, leading to shifts in wavelength. This shift can be identified through the cascade coupling of the FP cavity and ROTE cavity in the same mode. Experimental results further show that the shift in resonance wavelength increases with the concentration of CEA. The biosensor responded linearly to CEA concentrations ranging from 1 to 5 ng/mL with a limit of detection (LOD) of 0.5 ng/mL and a total Q factor of 9500. This research introduces a new avenue for identifying biomolecules and cancer biomarkers, which are crucial for early cancer detection.