类风湿性关节炎（RA）是一种复杂的疾病，既有遗传因素，也有环境因素。 2019 年，全球有 1800 万人患有 RA。 RA 的特征是关节内滑膜的持续炎症、软骨损失和骨侵蚀。酚类分子是植物中最普遍的次生代谢物，具有多种生物作用，有利于功能性膳食和营养保健品。这些化合物最近受到了广泛的关注，因为它们通过调节肿瘤坏死因子、丝裂原激活蛋白激酶、活化B细胞的核因子κ轻链增强子而具有抗氧化、抗炎、免疫调节和抗风湿活性。和 c-Jun N 末端激酶，以及其他预防特性。本文讨论了膳食多酚、其药理学特性以及治疗 RA 的创新递送技术，重点关注其可能的生物活性。尽管如此，多酚的商业化只有在确认其安全性并成功完成临床试验后才能实现。

Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental components. Globally, in 2019, 18 million people had RA. RA is characterized by persistent inflammation of the synovial membrane that lines the joints, cartilage loss, and bone erosion. Phenolic molecules are the most prevalent secondary metabolites in plants, with a diverse spectrum of biological actions that benefit functional meals and nutraceuticals. These compounds have received a lot of attention recently because they have antioxidant, anti-inflammatory, immunomodulatory, and anti-rheumatoid activity by modulating tumor necrosis factor, mitogen-activated protein kinase, nuclear factor kappa-light-chain-enhancer of activated B cells, and c-Jun N-terminal kinases, as well as other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, and innovative delivery technologies for the treatment of RA, with a focus on their possible biological activities. Nonetheless, commercialization of polyphenols may be achievable only after confirming their safety profile and completing successful clinical trials.