本研究旨在利用基于人群的队列分析儿科人群舌癌的临床病理特征和生存结果，这是一个现有数据有限的话题。从1975年至2018年诊断为舌癌的儿科患者是通过监测、流行病学来确定的和最终结果 (SEER) 数据库。使用卡普兰-迈耶分析评估存活率。通过对数秩检验进行单变量生存分析，而多变量分析则涉及 Cox 比例风险回归，以确定影响总生存 (OS) 的因素。根据 Cox 回归结果开发了预测列线图。总共确定了 97 名患有舌癌的儿科患者，诊断时的中位年龄为 15 岁（范围：1-19 岁）。肿瘤分为鳞状细胞癌（45.4%）、横纹肌肉瘤（RMS）（13.4%）和其他（41.2%）。在患者中，鳞状细胞癌在年龄较大的儿童中更常见，而横纹肌肉瘤在年龄较小的儿童中更常见。 Cox 比例风险回归显示组织学和手术是总生存率的重要独立预测因素。如果不进行手术，死亡的机会就会增加。此外，鳞状细胞癌或横纹肌肉瘤患者的生存率低于其他亚型患者。儿童舌癌很少见，且生存结果较差。这项研究强调了肿瘤组织学和手术干预在确定总体生存率方面的重要性，为小儿舌癌的临床决策提供了宝贵的见解。© 2024 Wiley periodicals LLC。

This study aims to analyze the clinicopathological characteristics and survival outcomes of tongue cancer in the pediatric population, a topic with limited existing data, using a population-based cohort.Pediatric patients diagnosed with tongue cancer from 1975 to 2018 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Survival rates were assessed using Kaplan-Meier analysis. Univariate survival analysis was conducted with the log-rank test, while multivariate analysis involved Cox proportional-hazards regression to identify factors influencing overall survival (OS). A predictive nomogram was developed based on Cox regression findings.In total, 97 pediatric patients with tongue cancer were identified, with a median age at diagnosis of 15 years (range: 1-19 years). Tumors were classified as squamous cell carcinoma (45.4%), rhabdomyosarcoma (RMS) (13.4%), and others (41.2%). Of the patients, squamous cell carcinoma was more common in older children, whereas rhabdomyosarcoma was more common in younger children. The Cox proportional hazard regression revealed that histology and surgery were significant independent predictors of overall survival. The chance of death increased with no surgery. Moreover, patients with squamous cell carcinoma or rhabdomyosarcoma have a poorer survival percentage than patients with other subtypes.Tongue cancer in children is rare and associated with poor survival outcomes. This study highlights the significance of tumor histology and surgical intervention in determining overall survival, offering valuable insights for clinical decision-making in pediatric tongue cancer.© 2024 Wiley Periodicals LLC.