唾液皮质醇分泌与口腔癌症之间的关系尚未完全阐明。因此，我们建议开展一项研究，以确定潜在恶性疾病 (PMD)、口腔鳞状细胞癌 (OSCC) 和健康个体的唾液皮质醇水平。横断面病例对照研究，在 80 名患者中进行阿根廷罗萨里奥国立大学牙科学院，2018 年 1 月至 2020 年 4 月期间。纳入了以白斑、地衣、红斑和鳞状细胞癌为代表的 40 例病例以及 40 例对照病例。吸烟习惯和饮酒习惯也包括在内。确定了压力的存在。采用罗氏电化学发光法（可追溯性：St by ID-MS）测量早晨唾液皮质醇水平。鳞状细胞癌患者的唾液皮质醇值升高。在所有病例中，患有 III 期肿瘤的个体的水平均高于 8.74 ng/ml。在对照组患者 (p<0.005) 和 PMD 患者 (p=0.009) 中检测到皮质醇水平与压力之间存在显着相关性。这种关联在 SCC 患者中并不显着 (p=0.999)。应用逻辑回归方法后，当根据吸烟和饮酒以及压力的存在调整比值比时，皮质醇水平与压力的存在之间的关联非常显着（p<0.001）。在有压力的患者中，出现无法检测到的皮质醇结果的可能性降低了 94%。 PMD 和 SCC 患者唾液皮质醇水平的增加与压力条件有关，能够产生导致细胞微环境免疫抑制的改变。

The relationship between salivary cortisol secretion and the presence of cancer in the oral cavity has not been completely clarified. Due to this, we proposed carrying out a study to determine salivary cortisol levels in patients with potentially malignant disorders (PMD), oral squamous cell carcinoma (OSCC) and healthy individuals.Cross-sectional case-control study, among 80 patients seen at the Faculty of Dentistry of the National University of Rosario, Argentina, between January 2018 and April 2020. 40 cases represented by Leukoplakia, Lichen, Erythroplakia and SCC and 40 controls were included. Smoking habit and alcohol consumption were included. The presence of stress was determined. Morning salivary cortisol levels were measured with the Roche electrochemiluminescence method (Traceability: St by ID-MS).Patients with SCC presented elevated salivary cortisol values. Individuals with stage III tumors showed levels higher than 8.74 ng/ml in all cases. A significant association between cortisol levels and stress was detected in patients in the control group (p<0.005) and in individuals with PMD (p=0.009). This association was not significant in patients with SCC (p=0.999). After applying the logistic regression method, when adjusting odds ratios according to tobacco and alcohol consumption and the presence of stress, the association between cortisol levels and presence of stress was highly significant (p<0.001). The possibility of presenting undetectable cortisol results was 94% lower in patients with stress.The increase in salivary cortisol levels in patients with PMD and SCC, is related to stress conditions, being able to generate alterations tending to immunosuppression of the cellular microenvironment.