聚多巴胺（PDA）因其独特的性质而成为癌症纳米医学中探索的多功能材料，为多功能药物输送平台提供了机会。本研究探讨了利用一锅合成法将 Fe、Gd 和 Mn 离子同时整合到基于多孔 PDA 的治疗诊断药物递送平台（分别称为 Ferritis、Gadolinis 和 Manganis）中的潜力。我们的研究涵盖了这些有效纳米制剂的形态、磁性、光热特性和细胞毒性特征。所获得的结构展现出球形形态、强大的磁响应和有前景的光热行为。所有提出的纳米粒子 (NP) 都表现出明显的顺磁性，揭示了 MRI 成像的对比潜力。弛豫值是造影效果的关键决定因素，与已使用的造影剂相比，其表现出具有竞争力或优越的性能。这些纳米制剂在近红外照射下还表现出强大的光热特性，展示了它们在癌症光热治疗中的可能应用。我们的研究结果为金属掺杂 PDA 纳米颗粒在癌症治疗诊断方面的潜力提供了见解。

Polydopamine (PDA) stands as a versatile material explored in cancer nanomedicine for its unique properties, offering opportunities for multifunctional drug delivery platforms. This study explores the potential of utilizing a one-pot synthesis to concurrently integrate Fe, Gd and Mn ions into porous PDA-based theranostic drug delivery platforms called Ferritis, Gadolinis and Manganis, respectively. Our investigation spans the morphology, magnetic properties, photothermal characteristics and cytotoxicity profiles of those potent nanoformulations. The obtained structures showcase a spherical morphology, robust magnetic response and promising photothermal behaviour. All of the presented nanoparticles (NPs) display pronounced paramagnetism, revealing contrasting potential for MRI imaging. Relaxivity values, a key determinant of contrast efficacy, demonstrated competitive or superior performance compared to established, used contrasting agents. These nanoformulations also exhibited robust photothermal properties under near infra-red irradiation, showcasing their possible application for photothermal therapy of cancer. Our findings provide insights into the potential of metal-doped PDA NPs for cancer theranostics.