放射治疗是盆腔腹部肿瘤的常规治疗方法。然而，它会对对辐射非常敏感的小肠和结直肠造成一些损害。放射性肠道损伤（RIII）影响放疗的预后，造成功能丧失的后遗症，对患者的生活质量造成长期损害。獐牙菜苦苷是一种苷，据报道可以预防多种疾病，包括但不限于糖尿病、高血压、动脉粥样硬化、关节炎、疟疾和腹部溃疡。然而，其对RIII的治疗效果和作用机制尚未确定。我们研究了獐牙菜苦苷是否对 RIII 具有保护作用。在本文中，我们使用辐照器创建辐射损伤的细胞和小鼠模型。预防性服用獐牙菜苦苷可以降低活性氧和超氧阴离子水平，从而减轻辐射引起的细胞损伤。獐牙菜苦苷还可以减弱小鼠的 RIII，其存活时间更长、体重减轻更少以及肠道屏障更完整就证明了这一点。我们还发现，受辐射的小鼠中初级胆汁酸的相对丰度有所增加，FXR 激动剂和獐牙菜苦苷均降低了初级胆汁酸的相对丰度，并且通过 cGAS-STING 途径减少了下游干扰素和炎症因子，从而减少了辐射引起的损伤。© 2024 年。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

Radiotherapy is the conventional treatment for pelvic abdominal tumors. However, it can cause some damage to the small intestine and colorectal, which are very sensitive to radiation. Radiation-induced intestinal injury (RIII) affects the prognosis of radiotherapy, causing sequelae of loss of function and long-term damage to patients' quality of life. Swertiamarin is a glycoside that has been reported to prevent a variety of diseases including but not limited to diabetes, hypertension, atherosclerosis, arthritis, malaria, and abdominal ulcers. However, its therapeutic effect and mechanism of action on RIII have not been established. We investigated whether swertiamarin has a protective effect against RIII. In this article, we use irradiator to create cellular and mouse models of radiation damage. Preventive administration of swertiamarin could reduce ROS and superoxide anion levels to mitigate the cellular damage caused by radiation. Swertiamarin also attenuated RIII in mice, as evidenced by longer survival, less weight loss and more complete intestinal barrier. We also found an increase in the relative abundance of primary bile acids in irradiated mice, which was reduced by both FXR agonists and swertiamarin, and a reduction in downstream interferon and inflammatory factors via the cGAS-STING pathway to reduce radiation-induced damage.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.