具有遗传性胰腺癌风险的个体包括具有胰腺癌 (PC) 种系遗传易感性和/或有明显 PC 家族史的高风险个体 (HRI)。此前的研究表明，HRI 中的 PC 监测可以降低​​ PC 诊断并延长生存期，因此建议对某些 HRI 进行胰腺监测。然而，最佳的监测策略仍然不确定，包括应使用哪种监测方式、应进行监测的频率以及应监测哪些 HRI 亚组。此外，在理想的情况下，PC 监控也应该具有成本效益。成本效益分析是一个很有价值的工具，可以考虑各种 PC 监控策略的成本、潜在的健康益处和风险。在这篇综述中，我们总结了遗传性胰腺癌 HRI 的各种 PC 监测策略的成本效益，并为该领域的未来工作提供了潜在的途径。此外，我们还纳入了新发糖尿病 (NoD) 患者（散发性 PC 的高危人群）的成本效益研究，作为比较。© 2024。作者。

Individuals with hereditary pancreatic cancer risk include high risk individuals (HRIs) with germline genetic susceptibility to pancreatic cancer (PC) and/or a strong family history of PC. Previously, studies have shown that PC surveillance in HRIs can downstage PC diagnosis and extend survival leading to pancreatic surveillance being recommended for certain HRIs. However, the optimal surveillance strategy remains uncertain, including which modalities should be used for surveillance, how frequently should surveillance be performed, and which sub-groups of HRIs should undergo surveillance. Additionally, in the ideal world PC surveillance should also be cost-effective. Cost-effectiveness analysis is a valuable tool that can consider the costs, potential health benefits, and risks among various PC surveillance strategies. In this review, we summarize the cost-effectiveness of various PC surveillance strategies for HRIs for hereditary pancreatic cancer and provide potential avenues for future work in this field. Additionally, we include cost-effectiveness studies among individuals with new-onset diabetes (NoD), a high-risk group for sporadic PC, as a comparison.© 2024. The Author(s).