黑色素瘤在皮肤癌相关死亡中占很大比例，根据诊断阶段和治疗效果，其生存结果各不相同。传统治疗虽然有效，但存在留下疤痕和全身副作用的风险。激光治疗提供了一种新兴的非手术替代方案，其中 CO2 激光在姑息治疗方面尤其显示出前景。使用 PubMed 进行了全面搜索，重点关注激光治疗黑色素瘤的治疗。该检索包括关于独立激光疗法和辅助激光疗法的研究，纳入标准需要同行评审的文章，详细说明原发性、复发性或转移性黑色素瘤的治疗结果。文献表明，按以下分类，黑色素瘤的激光疗法分为四种主要类型激光介质：固态、二极管、脉冲染料和气体 (CO2)。关于固态激光器治疗黑色素瘤的数据有限，其使用仍然存在争议。然而，一项使用高能脉冲钕激光的研究报告称，原发性黑色素瘤的 5 年生存率为 82.9%，且副作用极小。 CO2 激光疗法对于姑息治疗非常有效，一项研究显示，54.8% 的复发性黑色素瘤患者在消融后存活 5.4 年。对于转移性黑色素瘤，大量研究表明CO2激光治疗可以缓解症状并控制疾病。使用激光和基于免疫的疗法的联合疗法已证明可以增强疗效并增强免疫激活，凸显了激光疗法在黑色素瘤治疗中的潜力。虽然传统疗法仍然是原发性黑色素瘤的标准疗法，但激光疗法，特别是二氧化碳激光消融，在姑息治疗方面显示出巨大的前景。护理转移性黑色素瘤。仔细的患者选择和评估对于实现积极的结果至关重要。© 2024。作者。

Melanoma, accounting for a significant proportion of skin cancer-related deaths, has variable survival outcomes based on the stage at diagnosis and treatment efficacy. Traditional treatments, while effective, pose risks of scarring and systemic side effects. Laser therapy offers an emerging non-surgical alternative, with CO2 lasers particularly showing promise in palliative care.A comprehensive search was conducted using PubMed, focusing on laser therapy for melanoma treatment. The search included studies on both stand-alone and adjunct laser therapies, with inclusion criteria requiring peer-reviewed articles detailing treatment outcomes for primary, recurrent, or metastatic melanoma.The literature shows that laser therapy for melanoma falls into four major types when categorized by laser medium: solid-state, diode, pulse-dye, and gas (CO2). Data on solid-state lasers for melanoma are limited and their use remains controversial. However, one study with high-energy pulsed neodymium lasers reported a 5-year survival of 82.9% with minimal adverse effects for primary melanoma. CO2 laser therapy has been effective for palliative treatment, with one study showing 54.8% of patients with recurrent melanoma surviving 5.4 years post-ablation. For metastatic melanoma, numerous studies have shown that CO2 laser therapy can provide symptomatic relief and disease control. Combination therapies using lasers and immune-based therapies have demonstrated enhanced outcomes and immune activation, highlighting the potential of laser therapies in melanoma management.While traditional treatments remain the standard for primary melanoma, laser therapies, particularly CO2 laser ablation, show substantial promise in palliative care for metastatic melanoma. Careful patient selection and assessment are crucial for achieving positive outcomes.© 2024. The Author(s).