外阴癌根治性手术后静脉血栓栓塞（VTE）的发生率仍不清楚，术后化学预防的建议也各不相同。我们的目的是评估接受外阴癌手术的患者术后 VTE 的发生率，并确定有或没有淋巴结评估的根治性外阴切除术的 VTE 发生率是否有所不同。美国外科医生学会国家手术质量改进计划数据库中查询了以下患者的情况： 2012 年至 2020 年诊断为外阴癌，接受根治性外阴切除术，有或没有淋巴结评估。总结了临床特征和 30 天 VTE 发生率以及其他术后结果。使用卡方检验和 Fischer 精确检验以及适当时的 Kruskal-Wallis 和 Wilcoxon 秩和检验来比较变量。共有 1672 名患者因外阴癌接受了根治性外阴切除术。 11 名患者 (0.7%) 在手术后 30 天内经历了术后静脉血栓栓塞 (VTE)。单独进行根治性外阴切除术或通过任何方法进行淋巴结清扫术时，VTE 的发生率相似 (p = 0.116)。较长的手术时间 (p = 0.033) 和较长的术后住院时间 (p = 0.001) 与术后 VTE 风险增加相关。在该国家队列中，接受根治性外阴手术的患者术后 VTE 的发生率较低。与单独根治性外阴切除术相比，任何方法的腹股沟股淋巴结清扫术似乎都不是 VTE 的危险因素。需要进一步研究来确定延长 VTE 预防是否对该人群有益。版权所有 © 2024 Elsevier Inc. 保留所有权利。

The incidence of venous thromboembolism (VTE) following radical surgery for vulvar carcinoma remains poorly characterized, and recommendations for postoperative chemoprophylaxis are varied. Our objective was to assess the incidence of postoperative VTE in patients undergoing surgery for vulvar carcinoma and to determine if VTE incidence differs by radical vulvectomy with or without lymph node assessment.The American College of Surgeons National Surgical Quality Improvement Program database was queried for patients with a diagnosis of vulvar cancer undergoing radical vulvectomy with or without lymph node assessment from 2012 to 2020. Clinical characteristics and 30-day incidence of VTE as well as other postoperative outcomes were abstracted. Variables were compared using Chi-square test and Fischer's exact test, as well as Kruskal-Wallis and Wilcoxon rank sum tests where appropriate.A total of 1672 patients underwent radical vulvectomy for vulvar carcinoma. 11 patients (0.7%) experienced postoperative VTE within 30 days of surgery. The incidence of VTE was similar when radical vulvectomy was performed alone or with lymph node dissection by any method (p = 0.116). Longer operative times (p = 0.033) and greater postoperative length of stay (p = 0.001) were associated with increased risk of postoperative VTE.The incidence of postoperative VTE is low in patients undergoing radical vulvar surgery in this national cohort. Inguinofemoral lymph node dissection by any method does not appear to be a risk factor for VTE when compared to radical vulvectomy alone. Further research is needed to determine if extended VTE prophylaxis is beneficial in this population.Copyright © 2024 Elsevier Inc. All rights reserved.