自从纳米医学出现以来，医生们已经利用这些方法来预防、检测和治疗危及生命的疾病，特别是癌症。纳米粒子在癌症治疗中表现出显着的功效，展示了纳米技术在靶向药物输送方面的主要应用。胰腺癌是人类最致命的实体瘤。存活率低的原因在于其高度侵袭性、对化疗药物的内在耐药性以及缺乏成功的治疗方法，再加上非特异性症状导致的诊断延迟和缺乏快速诊断策略。尽管存在这些挑战，基于纳米技术的载体方法已成功应用于成像和治疗方法。克服胰腺癌的耐药性需要全面了解与疾病相关的微环境，从而为创新纳米载体铺平道路。由于血管化不足和肿瘤基质致密而阻碍化疗浸润，这是纳米技术解决的一个主要障碍。基于增强渗透性和保留效应的智能递送技术构成了最近开发的抗癌纳米载体的基础。这些进步旨在增强肿瘤部位的药物积累，为癌症的耐药性提供潜在的解决方案。应对胰腺癌治疗的挑战需要创新的疗法，而活性纳米载体的出现为提高治疗效果提供了一条有希望的途径。这篇综述专门探讨了纳米技术治疗胰腺癌的最新进展。版权所有 © 2024。由 Elsevier B.V. 出版。

Since the advent of nanomedicine, physicians have harnessed these approaches for the prophylaxis, detection, and therapy of life-threatening diseases, particularly cancer. Nanoparticles have demonstrated notable efficacy in cancer therapy, showcasing the primary application of nanotechnology in targeted drug delivery. Pancreatic cancer stands out as the most lethal solid tumor in humans. The low survival rate is attributed to its highly aggressive nature, intrinsic resistance to chemotherapeutics, and the lack of successful therapies, compounded by delayed diagnosis due to nonspecific symptoms and the absence of rapid diagnostic strategies. Despite these challenges, nanotechnology-based carrier methods have been successfully employed in imaging and therapy approaches. Overcoming drug resistance in pancreatic cancer necessitates a comprehensive understanding of the microenvironment associated with the disease, paving the way for innovative nanocarriers. Hindered chemotherapy infiltration, attributed to inadequate vascularization and a dense tumor stroma, is a major hurdle that nanotechnology addresses. Intelligent delivery techniques, based on the Enhanced Permeability and Retention effect, form the basis of recently developed anticancer nanocarriers. These advancements aim to enhance drug accumulation in tumor locations, offering a potential solution to the treatment-resistant nature of cancer. Addressing the challenges in pancreatic cancer treatment demands innovative therapies, and the emergence of active nanocarriers presents a promising avenue for enhancing outcomes. This review specifically delves into the latest advancements in nanotechnology for the treatment of pancreatic cancer.Copyright © 2024. Published by Elsevier B.V.