自主神经系统（ANS）支配全身器官和组织，维持各系统之间的功能平衡。进一步的研究表明，ANS的过度激活不仅会破坏体内平衡​​，还可能促进肿瘤的形成。此外，肿瘤微环境中神经与肿瘤细胞之间的动态相互作用也调节肿瘤的进展。一方面，神经受到肿瘤细胞的被动侵袭，即神经周围侵犯（PNI）。另一方面，与正常组织相比，肿瘤组织受到更丰富的神经支配，神经可以通过调节肿瘤的增殖、转移和耐药来影响肿瘤的进展。大量研究表明，神经-肿瘤串扰，包括PNI和神经支配，与患者的预后密切相关，并有助于癌痛的形成，从而显着恶化患者的生活质量。这些发现表明神经-肿瘤串扰代表了未来抗肿瘤治疗和癌症疼痛管理的潜在目标。在这篇综述中，我们系统地描述了神经-肿瘤串扰调节肿瘤发生和进展的机制。版权所有 © 2024。由 Elsevier B.V. 出版。

The autonomic nerve system (ANS) innervates organs and tissues throughout the body and maintains functional balance among various systems. Further investigations have shown that excessive activation of ANS not only causes disruption of homeostasis, but also may promote tumor formation. In addition, the dynamic interaction between nerve and tumor cells in the tumor microenvironment also regulate tumor progression. On the one hand, nerves are passively invaded by tumor cells, that is, perineural invasion (PNI). On the other hand, compared with normal tissues, tumor tissues are subject to more abundant innervation, and nerves can influence tumor progression through regulating tumor proliferation, metastasis and drug resistance. A large number of studies have shown that nerve-tumor crosstalk, including PNI and innervation, is closely related to the prognosis of patients, and contributes to the formation of cancer pain, which significantly deteriorates the quality of life for patients. These findings suggest that nerve-tumor crosstalk represents a potential target for anti-tumor therapies and the management of cancer pain in the future. In this review, we systematically describe the mechanism by which nerve-tumor crosstalk regulates tumorigenesis and progression.Copyright © 2024. Published by Elsevier B.V.