消化系统的各种临床症状，如感染性、炎症性和恶性疾病，对患者的生活质量和整体健康产生深远影响。因此，寻找更有效的药物是非常重要和紧迫的。纳米酶是一类新型纳米材料，将纳米材料的生物特性与酶的催化活性相结合，并已被设计用于各种生物医学应用，包括复杂的胃肠道疾病 (GI)。特别是，由于其独特的金属配位结构和最大化原子利用效率的能力，具有原子分散金属中心的单原子纳米酶（SAzymes）正在成为天然酶更可行的替代品。由于制备工艺的多样化和复杂性，传统的纳米酶设计策略已无法满足当前高效、多样化SAzymes设计的要求。因此，本综述强调了SAzymes的设计理念和合成策略，以及相应的生物酶样活性，如超氧化物歧化酶（SOD）、过氧化物酶（POD）、氧化酶（OXD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）。然后总结了 SAzymes 在胃肠道疾病中的各种应用，这应该鼓励对纳米酶的进一步研究，以实现更好的应用特性。© 2024。作者。

Various clinical symptoms of digestive system, such as infectious, inflammatory, and malignant disorders, have a profound impact on the quality of life and overall health of patients. Therefore, the chase for more potent medicines is both highly significant and urgent. Nanozymes, a novel class of nanomaterials, amalgamate the biological properties of nanomaterials with the catalytic activity of enzymes, and have been engineered for various biomedical applications, including complex gastrointestinal diseases (GI). Particularly, because of their distinctive metal coordination structure and ability to maximize atom use efficiency, single-atom nanozymes (SAzymes) with atomically scattered metal centers are becoming a more viable substitute for natural enzymes. Traditional nanozyme design strategies are no longer able to meet the current requirements for efficient and diverse SAzymes design due to the diversification and complexity of preparation processes. As a result, this review emphasizes the design concept and the synthesis strategy of SAzymes, and corresponding bioenzyme-like activities, such as superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD), catalase (CAT), and glutathione peroxidase (GPx). Then the various application of SAzymes in GI illnesses are summarized, which should encourage further research into nanozymes to achieve better application characteristics.© 2024. The Author(s).