轴向姿势异常 (PA) 会使帕金森病 (PD) 的症状失效。 PA 的危险因素尚不清楚。我们试图评估 PD 前 4-6 年的 PA 发病率和危险因素。我们纳入了帕金森病进展标志物计划 (PPMI) 队列中的 441 名 PD 患者，并提供了诊断时和 4 年后的数据跟进。 PA 的定义是根据运动障碍协会赞助的统一帕金森病评定量表 (MDS-UPDRS) 修订版中非治疗条件下的姿势项目 ≥ 2。 Kruskal-Wallis 检验用于比较无 PA（“无 PA”）、发病时有 PA（“基线-PA”）和随访期间发生 PA（“发展 PA”）患者的特征。为了确定 PA 发展的预测因子，考虑了人口统计学、临床和治疗变量，进行了单变量和多变量 Cox 回归分析。10.9% 的患者在基线时表现出 PA，23.7% 的患者在诊断后的前 4-6 年内出现 PA。年龄较大，恶性表型，MDS-UPDRS 较高，第 III 部分，Hoehn

Axial postural abnormalities (PA) are invalidating symptoms of Parkinson's disease (PD). Risk factors for PA are unknown.We sought to evaluate PA incidence and risk factors over the first 4-6 years of PD.We included 441 PD patients from the Parkinson's Progression Markers Initiative (PPMI) cohort with data at diagnosis and after 4-year follow-up. PA was defined according to a posture item ≥ 2 at the Movement Disorder Society-sponsored-revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) in Off therapeutic condition. The Kruskal-Wallis test was used to compare characteristics of patients without PA ('no-PA'), with PA at disease onset ('baseline-PA'), and PA developed during follow-up ('develop-PA'). To identify predictors of PA development, univariate and multivariate Cox regression analyses were performed considering demographic, clinical and therapeutic variables.10.9% of patients showed PA at baseline and 23.7% developed PA within the first 4-6 years since diagnosis. Older age, malignant phenotype, higher MDS-UPDRS part III, Hoehn & Yahr, and dysautonomia (SCOPA-AUT) score, and lower levels of physical activity were predictors of PA development at the univariate analysis. Older age (Hazard ratio [HR] per year: 1.041) and higher MDS-UPDRS part III score (HR per point: 1.035) survived as PA development predictors in the multivariate analysis.PPMI cohort data show that > 30% of PD patients present PA within the first 4-6 years of disease. Older age at onset and higher motor burden are associated with a higher risk for PA development. The protective role of physical activity merits to be further investigated.© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.