近红外（NIR）响应纳米颗粒是多模式光疗的重要平台。重要的是，同时近红外触发的光动力（PDT）和光热（PTT）疗法由于协同作用，是提高光疗纳米颗粒抗肿瘤效率的有效方法。在此，设计并合成了一种基于硼二吡咯亚甲基（BODIPY）的具有增强的电子供体-受体-供体（D-A-D）结构的两亲性染料（BDP-AP），它可以自组装成稳定的纳米颗粒（BDP-AP NPs），用于协同 NIR 触发的 PDT/PTT 治疗。 BDP-AP NPs同步产生单线态氧(1O2)并实现了卓越的光热转换效率(61.42%)。体外和体内实验表明，BDP-AP NPs 具有可忽略不计的暗细胞毒性和输注抗癌性能。 BDP-AP NP 为构建 PDT/PTT 协同 NIR 纳米制剂以提高未来光诱导癌症治疗的效率提供了宝贵的指导。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Near-infrared (NIR) responsive nanoparticles are an important platform for multimodal phototherapy. Importantly, the simultaneous NIR-triggered photodynamic (PDT) and photothermal (PTT) therapy is a powerful approach to increase the antitumor efficiency of phototherapic nanoparticles due to the synergistic effect. Herein, a boron dipyrromethene (BODIPY)-based amphiphilic dye with enhanced electron donor-acceptor-donor (D-A-D) structure (BDP-AP) was designed and synthesized, which could self-assemble into stable nanoparticles (BDP-AP NPs) for the synergistic NIR-triggered PDT/PTT therapy. BDP-AP NPs synchronously generated singlet oxygen (1O2) and achieved preeminent photothermal conversion efficiency (61.42%). The in vitro and in vivo experiments showed that BDP-AP NPs possessed negligible dark cytotoxicity and infusive anticancer performance. BDP-AP NPs provide valuable guidance for the construction of PDT/PTT-synergistic NIR nanoagents to improve the efficiency of photoinduced cancer therapy in the future.Copyright © 2024 Elsevier Inc. All rights reserved.