小气道阻塞和死亡率：英国生物银行的调查结果。
Small airways obstruction and mortality: Findings from the UK Biobank.
发表日期：2024 May 24
作者：
Valentina Quintero Santofimio, Ben Knox-Brown, James Potts, Samuel Bartlett-Pestell, Johanna Feary, Andre Fs Amaral
来源：
CHEST
摘要：
小气道阻塞 (SAO) 在普通人群中很常见。随着时间的推移，它与呼吸道症状、心脏代谢疾病和慢性阻塞性肺病的进展有关。 SAO 是否可以预测死亡率在很大程度上尚不清楚。肺活量测定法定义的 SAO 与死亡率增加相关吗？我们分析了英国生物银行 252,877 名基线年龄为 40-69 岁的成年参与者的数据，他们提供了高质量的肺量计测量结果。我们将SAO定义为3秒用力呼气量与6秒用力呼气量小于正常下限（FEV3/FEV6
Small airways obstruction (SAO) is common in general populations. It has been associated with respiratory symptoms, cardiometabolic diseases and progression to chronic obstructive pulmonary disease over time. Whether SAO predicts mortality is largely unknown.Is spirometry-defined SAO associated with increased mortality?We analysed data from 252,877 adult participants, aged 40-69 at baseline, in the UK Biobank who had provided good quality spirometry measurements. We defined SAO as the ratio of the forced expiratory volume in three seconds to the forced expiratory volume in six seconds less than the lower limit of normal (FEV3/FEV6