T 细胞激活的 V 结构域 Ig 抑制蛋白 (VISTA) 是最近鉴定的免疫调节蛋白 B7 家族的成员。它对于维持 T 细胞静止至关重要，并对肿瘤的免疫反应发挥重要的调节影响。越来越多的临床证据表明，VISTA 对肿瘤免疫的影响比最初假设的更加微妙。尽管这些发现增加了我们对 VISTA 功能的理解的复杂性，但它们也为科学探究和潜在治疗靶点提供了新的途径。在这篇综述中，我们仔细研究了有关 VISTA 在各种恶性肿瘤中表达的最新文献，旨在阐明其在肿瘤微环境和癌症免疫治疗中的复杂作用。版权所有 © 2024。由 Elsevier Ltd 出版。

V-domain Ig suppressor of T cell activation (VISTA) is a recently identified member of the B7 family of immunoregulatory proteins. It is pivotal for maintaining T cell quiescence and exerts a significant regulatory influence on the immune response to tumors. Accumulating clinical evidence suggests that the influence of VISTA on tumor immunity is more nuanced than initially postulated. Although these revelations add layers of complexity to our understanding of the function of VISTA, they also offer novel avenues for scientific inquiry and potential therapeutic targets. In this review, we scrutinize the current literature pertaining to the expression of VISTA in various of malignancies, aiming to elucidate its intricate roles within the tumor microenvironment and in cancer immunotherapy.Copyright © 2024. Published by Elsevier Ltd.