全球前列腺癌发病率和死亡率不断上升，显着影响男性患者的寿命，因此迫切需要了解其致病机制以及调节肿瘤进展的相关分子变化，以进行有效的预防和治疗。 RNA修饰是一个重要的转录后调控过程，深刻影响肿瘤细胞的生长和代谢，塑造细胞命运。已知超过 170 种 RNA 修饰方法，其中突出的研究集中在 N6-甲基腺苷、N7-甲基鸟苷、N1-甲基腺苷、5-甲基胞苷、假尿苷和 N4-乙酰胞苷修饰。这些改变在转录后复杂地调节编码和非编码RNA，影响RNA和蛋白质表达水平的稳定性。本文深入探讨了与前列腺癌肿瘤细胞、肿瘤微环境和核心信号分子雄激素受体中各种 RNA 修饰相关的最新进展和挑战。旨在为前列腺癌的分子诊断、治疗策略和改善预后提供新的研究靶点和途径。版权所有 © 2024 张，刘，吴，顾，邹，刘，耿，毛，罗，郭，张和姚。

The increasing incidence and mortality of prostate cancer worldwide significantly impact the life span of male patients, emphasizing the urgency of understanding its pathogenic mechanism and associated molecular changes that regulate tumor progression for effective prevention and treatment. RNA modification, an important post-transcriptional regulatory process, profoundly influences tumor cell growth and metabolism, shaping cell fate. Over 170 RNA modification methods are known, with prominent research focusing on N6-methyladenosine, N7-methylguanosine, N1-methyladenosine, 5-methylcytidine, pseudouridine, and N4-acetylcytidine modifications. These alterations intricately regulate coding and non-coding RNA post-transcriptionally, affecting the stability of RNA and protein expression levels. This article delves into the latest advancements and challenges associated with various RNA modifications in prostate cancer tumor cells, tumor microenvironment, and core signaling molecule androgen receptors. It aims to provide new research targets and avenues for molecular diagnosis, treatment strategies, and improvement of the prognosis in prostate cancer.Copyright © 2024 Zhang, Liu, Wu, Gu, Zou, Liu, Geng, Mao, Luo, Guo, Zhang and Yao.