芒柄花素 (FMNT) 是类黄酮的次生代谢产物，富含豆科植物和禾本科植物，例如黄芪 [豆科；黄芪]和燕麦[禾本科]。黄芪在中国、韩国和蒙古等亚洲国家传统上用于治疗炎症性疾病、免疫紊乱和癌症。近年来，人们发现炎症和氧化应激与许多疾病有关。大量药理学研究表明，FMNT是黄芪的重要生物活性代谢产物，具有很强的抗炎和抗氧化作用。本综述的重点是提供关于 FMNT 及其衍生物在体外和体内对抗炎症和氧化应激的分子靶点和机制的功效的全面和最新的发现。分析了2013年至2023年FMNT抗炎症和氧化应激的相关文献。 FMNT 具有抗氧化和抗炎潜力，对多种疾病表现出轻微或无毒性。此外，在医学领域，FMNT在预防和治疗癌症、神经系统疾病、纤维化疾病、过敏性疾病、代谢性疾病、心血管疾病、胃肠道疾病和自身免疫性疾病等方面显示出潜力。因此，未来有望应用于更多医疗、食品、化妆品行业的产品中。版权所有 © 2024 丁、包、梁、张、李、杨、曾。

Formononetin (FMNT) is a secondary metabolite of flavonoids abundant in legumes and graminaceous plants such as Astragalus mongholicus Bunge [Fabaceae; Astragali radix] and Avena sativa L. [Poaceae]. Astragalus is traditionally used in Asia countries such as China, Korea and Mongolia to treat inflammatory diseases, immune disorders and cancers. In recent years, inflammation and oxidative stress have been found to be associated with many diseases. A large number of pharmacological studies have shown that FMNT, an important bioactive metabolite of Astragalus, has a profoundly anti-inflammatory and antioxidant potential. This review focuses on providing comprehensive and up-to-date findings on the efficacy of the molecular targets and mechanisms involve of FMNT and its derivatives against inflammation and oxidative stress in both in vitro and in vivo. Relevant literature on FMNT against inflammation and oxidative stress between 2013 and 2023 were analyzed. FMNT has antioxidant and anti-inflammatory potential and shows mild or no toxicity in various diseases. Moreover, in the medical field, FMNT has shown potential in the prevention and treatment of cancers, neurological diseases, fibrotic diseases, allergic diseases, metabolic diseases, cardiovascular diseases, gastrointestinal diseases and autoimmune diseases. Thus, it is expected to be utilized in more products in the medical, food and cosmetic industries in the future.Copyright © 2024 Ding, Bao, Liang, Zhang, Li, Yang and Zeng.