据报道，炎症与贫血有关。作为一种新型炎症标志物，全身免疫炎症指数（SII）尚未与贫血相关进行研究。本研究的目的是调查 SII 与贫血之间可能的关系。这项回顾性横断面调查是使用 2005-2018 年全国健康和营养检查调查 (NHANES) 人群的数据进行的。总共包括 19851 名 18 岁以上的美国成年人。 SII计算为血小板计数×中性粒细胞计数/淋巴细胞计数。贫血定义为男性血红蛋白 (Hgb) 水平 < 13 g/dL，女性血红蛋白 (Hgb) 水平 < 12 g/dL。采用Logistic回归分析、亚组分析和敏感性分析来探讨SII与贫血之间的关系。我们的研究共纳入19851名患者，其中1501名（7.6%）患有贫血。调整所有协变量后，多变量逻辑回归分析显示，较高的 SII（In-transform）水平与贫血可能性增加相关（OR=1.51，95% CI：1.36-1.68，P<0.001）。 SII 与贫血之间的关联呈现出非线性关系。 SII与贫血呈正相关，且与贫血的严重程度相关。亚组分析显示，除性别外，这种正相关性与年龄、家庭收入、体重指数、高血压、肾病和癌症没有显着相关性。此外，敏感性分析证实了我们结果的稳健性。我们的研究表明，SII 与贫血呈正相关，尤其是在女性参与者中。而这种正相关性与贫血的严重程度有关。仍需要进一步的大规模前瞻性研究来分析 SII 在贫血中的作用。版权所有 © 2024 Chen、Xiao、Cai、Lu、Liu、Dong、Zheng、Song、Sun、Wang 和 Shaw。

Inflammation has been reported to be related to anemia. As a novel inflammatory marker, Systemic immune-inflammation index (SII) has not been studied with Anemia. The aim of this study was to investigate the possible relationship between SII and anemia.This retrospective cross-sectional survey was conducted using data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) population. In total, 19851 American adults aged ≥18 years were included. SII was calculated as the platelet count×neutrophil count/lymphocyte count. Anemia was defined as hemoglobin (Hgb) levels of < 13 g/dL in males and < 12 g/dL in females. Logistic regression analyses, subgroup analyses and sensitivity analyses were performed to investigate the relationship between SII and anemia.Our study included a total of 19851 patients, of which 1501 (7.6%) had anemia. After adjusting for all covariates, the multivariate logistic regression analysis showed that a higher SII (In-transform) level was associated with increased likelihood of anemia (OR=1.51, 95% CI: 1.36-1.68, P<0.001). The association between SII and anemia exhibited a nonlinear manner. The positive correlation between SII and anemia was related to the severity of anemia. Subgroup analysis showed that there was no significant dependence on age, family income, body mass index, hypertension, kidney disease and cancer except gender on this positive association. Furthermore, sensitivity analyses confirmed the robustness of our results.Our study demonstrated that SII was positively associated with anemia especially among female participants. And this positive correlation was related to the severity of anemia. Further large-scale prospective studies are still needed to analyze the role of SII in anemia.Copyright © 2024 Chen, Xiao, Cai, Lu, Liu, Dong, Zheng, Song, Sun, Wang and Xiao.