肝细胞癌（HCC）是世界上癌症相关死亡的重要原因。 HCC的发生发展与非编码RNA（ncRNA）的异常调控密切相关，如微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）。癌症生物学中的重要生物学途径，例如细胞增殖、死亡和转移，受到这些调节基因表达的 ncRNA 的影响。 HCC 中非编码 RNA 的异常表达提出了它们作为诊断、预后和治疗目标的新生物标志物的可能性。此外，通过控制癌症相关基因的表达，miRNA 可以充当肿瘤抑制基因或癌基因。另一方面，lncRNA 通过与细胞内其他分子相互作用，在癌症的进展中发挥作用，进而影响染色质重塑、转录和转录后过程等过程。当前的研究强调了 ncRNA 驱动的调控系统在 HCC 中的重要性，该研究揭示了肿瘤行为和治疗反应。这项研究强调了 ncRNA 通过使用精准医学方法增强现有 HCC 护理方法来改善这种疑难疾病患者预后的巨大潜力。版权所有 © 2024 Tian, Zhuang, Liu, Wang, Liu, Huang, Wang,凌、王、冯、屠。

Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the world. The development and progression of HCC are closely correlated with the abnormal regulation of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Important biological pathways in cancer biology, such as cell proliferation, death, and metastasis, are impacted by these ncRNAs, which modulate gene expression. The abnormal expression of non-coding RNAs in HCC raises the possibility that they could be applied as new biomarkers for diagnosis, prognosis, and treatment targets. Furthermore, by controlling the expression of cancer-related genes, miRNAs can function as either tumor suppressors or oncogenes. On the other hand, lncRNAs play a role in the advancement of cancer by interacting with other molecules within the cell, which, in turn, affects processes such as chromatin remodeling, transcription, and post-transcriptional processes. The importance of ncRNA-driven regulatory systems in HCC is being highlighted by current research, which sheds light on tumor behavior and therapy response. This research highlights the great potential of ncRNAs to improve patient outcomes in this difficult disease landscape by augmenting the present methods of HCC care through the use of precision medicine approaches.Copyright © 2024 Tian, Zhang, Liu, Wang, Liu, Huang, Wang, Ling, Wang, Feng and Tu.