研究动态
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基于聚糖的支架和纳米粒子作为癌症治疗中的药物输送系统。

Glycan-based scaffolds and nanoparticles as drug delivery system in cancer therapy.

发表日期:2024
作者: Henan Qin, Yibin Teng, Rui Dai, Aman Wang, Jiwei Liu
来源: Frontiers in Immunology

摘要:

基于聚糖的支架具有独特的高特异性、多功能性、低免疫原性以及模仿天然碳水化合物的能力,使其成为用于癌症治疗的有吸引力的候选者。这些支架由聚糖组成,聚糖是在人体内具有良好生物相容性的生物聚合物,可用于药物输送。基于聚糖的支架的多功能性允许调节药物活性并靶向递送至特定细胞或组织,从而增加药物的效力并减少副作用。尽管前景广阔,但基于聚糖的支架的设计和生产仍然存在技术挑战,并且其治疗功效和特异性也存在局限性。版权所有 © 2024qin、Teng、Dai、Wang 和 Liu。
Glycan-based scaffolds are unique in their high specificity, versatility, low immunogenicity, and ability to mimic natural carbohydrates, making them attractive candidates for use in cancer treatment. These scaffolds are made up of glycans, which are biopolymers with well biocompatibility in the human body that can be used for drug delivery. The versatility of glycan-based scaffolds allows for the modulation of drug activity and targeted delivery to specific cells or tissues, which increases the potency of drugs and reduces side effects. Despite their promise, there are still technical challenges in the design and production of glycan-based scaffolds, as well as limitations in their therapeutic efficacy and specificity.Copyright © 2024 Qin, Teng, Dai, Wang and Liu.