眼外皮脂腺癌（SC），特别是头颈部以外的皮脂腺癌，非常罕见，且描述较少。本研究旨在探讨非头颈部 SC 的流行病学并确定其预后因素，描述非头颈部 SC 的可能相关因素。监测、流行病学和最终结果数据库中的 17 个登记处回顾性收集了 2000 年至 2020 年头颈部以外 SC 患者的数据。总生存期 (OS) 和疾病- 特异性生存（DSS）是主要终点。通过Kaplan-Meier曲线进行生存分析，并使用Cox比例风险模型进行多变量分析。共识别出1,237例头颈部以外的SC患者。整个患者队列诊断时的平均年龄为 67.7 岁（30 至 90 岁），平均肿瘤大小为 2.2 厘米（0.1-16 厘米）。患有远处疾病的患者比患有局部疾病和区域疾病的患者经历了最低的 OS（平均 29.5 个月）（p < 0.0001）。多变量分析显示，年龄、肿瘤大小和分期是 OS 的独立决定因素；年龄、分期和原发部位是 DSS 的独立决定因素。肿瘤分级和淋巴结状态对生存的预后价值较小。未分化肿瘤有远处转移的趋势，尤其是躯干原发部位的肿瘤。非头颈部SC的预后极好，而远处病变的生存率很差。对于未分化肿瘤，尤其是位于躯干区域且肿瘤体积较大的肿瘤，可考虑进行远处转移筛查。版权所有 © 2024 Chen，Hao，Chou，Yang。

Extraocular sebaceous carcinoma (SC), particularly those outside the head and neck region, is rare and not well-described.This study aimed to explore the epidemiology and identify the prognostic factors of non-head and neck SC, describe the possible relevant factors of distant metastasis, and provide implications for distant metastasis screening.Data from the 17 registries in the Surveillance, Epidemiology, and End Results database were retrospectively collected for patients with SC outside the head and neck from 2000 through 2020. Overall survival (OS) and disease-specific survival (DSS) were the primary endpoints. Survival analysis was conducted through Kaplan-Meier curves, and multivariate analysis was carried out using Cox proportional hazard models.A total of 1,237 patients with SC outside the head and neck were identified. The mean age at diagnosis of the entire patient cohort was 67.7 years (30 to 90+ years), and the mean tumor size was 2.2 cm (0.1-16 cm). Patients with distant disease experienced the lowest OS (mean, 29.5 months) than those with localized disease and regional disease (p < 0.0001). Multivariate analysis revealed that age, tumor size, and stage were independent determinants of OS; age, stage, and primary site were independent determinants of DSS. Tumor grade and lymph node status had less prognostic value for survival. Undifferentiated tumors have a trend toward distant metastasis, especially those at the primary site of the trunk.The prognosis of the non-head and neck SC is excellent, while the survival of distant disease is very poor. Distant metastasis screening can be considered for undifferentiated tumors, especially those located in the trunk region with large tumor sizes.Copyright © 2024 Chen, Hao, Chou and Yang.