骨肉瘤 (OS) 是一种常见的骨实体恶性肿瘤，主要影响青少年，尤其是 14-19 岁的男孩。由于其高迁移能力，这种侵袭性癌症通常会导致致命的肺癌。实验证据表明程序性细胞死亡（PCD）在骨肉瘤的发展中起着至关重要的作用。各种形式的 PCD，包括细胞凋亡、铁死亡、自噬、坏死性凋亡和细胞焦亡，对骨肉瘤的进展有显着影响。此外，STAT3/c-Myc信号通路、JNK信号通路、PI3k/AKT/mTOR信号通路、WNT/β-catenin信号通路、RhoA信号通路等不同信号通路可通过调节骨肉瘤中的PCD影响骨肉瘤的发生发展。细胞。因此，针对 PCD 和相关信号通路可以为治疗骨肉瘤提供一种有前景的治疗方法。© 2024 作者。约翰·威利出版的癌症医学

Osteosarcoma (OS) is a prevalent bone solid malignancy that primarily affects adolescents, particularly boys aged 14-19. This aggressive form of cancer often leads to deadly lung cancer due to its high migration ability. Experimental evidence suggests that programmed cell death (PCD) plays a crucial role in the development of osteosarcoma. Various forms of PCD, including apoptosis, ferroptosis, autophagy, necroptosis, and pyroptosis, contribute significantly to the progression of osteosarcoma. Additionally, different signaling pathways such as STAT3/c-Myc signal pathway, JNK signl pathway, PI3k/AKT/mTOR signal pathway, WNT/β-catenin signal pathway, and RhoA signal pathway can influence the development of osteosarcoma by regulating PCD in osteosarcoma cell. Therefore, targeting PCD and the associated signaling pathways could offer a promising therapeutic approach for treating osteosarcoma.© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.