许多观察性研究调查了妊娠期高血压疾病（HDP）与随后的妇科肿瘤风险之间的潜在联系，但研究结果并不一致。在本研究中，我们利用孟德尔随机化 (MR) 方法来评估 HDP 对卵巢癌、宫颈癌、子宫内膜癌、乳腺癌和子宫肌瘤未来风险的影响，并控制混杂因素。全基因组关联研究 (GWAS)与 HDP 相关的摘要数据来自 FinnGen 数据库（10,736 例病例和 136,325 例对照）。妇科肿瘤结果提取自 IEU Open GWAS 项目和 UK Biobank（47,690 例病例和 1, 092,073 例对照）。选择逆方差加权（IVW）方法作为MR分析的主要方法，辅以MR-Egger、加权中位数、加权模型、简单模型方法、MR多效性残差和和离群值（MR-PRESSO）检验以及留-一出法。在调整收缩压 (SBP)、体重指数 (BMI) 和 2 型糖尿病 (T2DM) 后进行多变量 MR (MVMR) 分析。我们的单变量 MR 分析 (UVMR) 结果显示 HDP 与糖尿病风险之间没有显着关系。卵巢癌（比值比[OR] = 0.924，p = 0.360）、宫颈癌（OR = 1.230，p = 0.738）、子宫内膜癌（OR = 1.006，p = 0.949）、子宫肌瘤（OR = 1.15） 5、p = 0.158 ）和乳腺癌（OR = 0.792，p = 0.241）通过 IVW 测试。在妊娠高血压和先兆子痫/子痫中观察到类似的结果。此外，我们的研究既没有检测到异质性，也没有检测到多效性。在调整 SBP、BMI 和 T2DM 后，MVMR 分析也没有提供 HDP 与常见妇科肿瘤之间存在因果关系的证据。我们发现欧洲人群中 HDP 与卵巢癌、宫颈癌、子宫内膜癌、乳腺癌和子宫肌瘤之间没有因果关系。然而，目前的分析并未探讨 HDP 对不同种族人群妇科肿瘤亚型的影响，这可能需要额外的研究。© 2024 作者。约翰·威利出版的癌症医学

Numerous observational studies have investigated the potential link between hypertensive disorders of pregnancy (HDPs) and the subsequent risks of gynecologic tumors, yet the findings have been inconsistent. In this study, we utilized Mendelian randomization (MR) approach to assess the influence of HDPs on the future risks of ovarian, cervical, endometrial, and breast cancer and uterine fibroids, controlling for confounding factors.The genome-wide association studies (GWAS) summary data relevant to HDPs was obtained from the FinnGen databases (10,736 cases and 136,325 controls). Gynecologic tumor outcomes were extracted from the IEU Open GWAS project and UK Biobank (47,690 cases and 1, 092,073 controls). The inverse variance weighted (IVW) approach was selected as the principal method for MR analysis, supplemented by MR-Egger, weighted median, weighted model, simple model methods, MR pleiotropy residual sum and outlier (MR-PRESSO) test, and leave-one-out method. Multivariate MR (MVMR) analysis was conducted after adjusting systolic blood pressure (SBP), body mass index (BMI) and type 2 diabetes mellitus (T2DM).Our univariate MR analysis (UVMR) results revealed no significant relationship between HDPs and the risks of ovarian cancer (odds ratio [OR] = 0.924, p = 0.360), cervical cancer (OR = 1.230, p = 0.738), endometrial cancer (OR = 1.006, p = 0.949), uterine fibroids (OR = 1.155, p = 0.158), and breast cancer (OR = 0.792, p = 0.241) by IVW test. Similar results were observed in gestational hypertension and preeclampsia/eclampsia. Additionally, our study detected neither heterogeneity nor pleiotropy. MVMR analysis also provided no evidence of a causal association between HDPs and common gynecologic tumors after adjusting SBP, BMI, and T2DM.We discovered no causal relationship between HDPs and ovarian, cervical, endometrial, breast cancer, and uterine fibroids in European populations. However, present analysis did not explore the effect of HDPs on the subtypes of gynecologic tumors across varied ethnic populations, which may require additional research.© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.