衰老导致细胞突变和损伤的积累，增加衰老、细胞凋亡和恶性转化的风险。细胞衰老是衰老的关键，它既可以防止细胞转化，也可以阻止癌症进展。其特点是稳定的细胞周期停滞、广泛的大分子变化、促炎特征和基因表达改变。然而，这些不同的衰老细胞亚群是由独特的内在程序产生还是受到其环境背景的影响仍有待确定。多种转录调节因子和染色质修饰因子促成了这些改变。特殊的富含 AT 的序列结合蛋白 1 (SATB1) 是这一过程中的关键调节因子，它通过将染色质构造成环结构域并锚定 DNA 元件来协调基因表达。这篇综述概述了细胞衰老，并深入探讨了 SATB1 在衰老相关疾病中的作用。它强调了 SATB1 在制定抗衰老和抗癌策略方面的潜力，可能有助于提高生活质量和解决与衰老相关的疾病。© 2024 Wiley periodicals LLC。

Aging leads to an accumulation of cellular mutations and damage, increasing the risk of senescence, apoptosis, and malignant transformation. Cellular senescence, which is pivotal in aging, acts as both a guard against cellular transformation and as a check against cancer progression. It is marked by stable cell cycle arrest, widespread macromolecular changes, a pro-inflammatory profile, and altered gene expression. However, it remains to be determined whether these differing subsets of senescent cells result from unique intrinsic programs or are influenced by their environmental contexts. Multiple transcription regulators and chromatin modifiers contribute to these alterations. Special AT-rich sequence-binding protein 1 (SATB1) stands out as a crucial regulator in this process, orchestrating gene expression by structuring chromatin into loop domains and anchoring DNA elements. This review provides an overview of cellular senescence and delves into the role of SATB1 in senescence-related diseases. It highlights SATB1's potential in developing antiaging and anticancer strategies, potentially contributing to improved quality of life and addressing aging-related diseases.© 2024 Wiley Periodicals LLC.