目前的癌症治疗方法已显示出抑制肿瘤的巨大潜力。然而，高剂量的化疗方案会导致影响正常身体细胞的各种并发症。肿瘤细胞还会在整个治疗方案中对处方药物产生耐药性，增加癌症复发的风险。节拍化疗是一种现代治疗方法，涉及持续低剂量给药，让药物有足够的时间发挥作用。与传统化疗相比，该方法确保药物的毒性降至最低。在各种癌症治疗中，纳米颗粒已显示出将药物递送至肿瘤细胞的功效。将纳米粒子与节律化疗相结合可以产生更好的治疗效果。这种组合可以刺激免疫系统，提高免疫细胞对癌细胞的识别能力。临床和临床前试验的证据支持使用节拍式递送载药纳米颗粒。本综述重点关注纳米颗粒的功能化，以改善药物输送和抑制肿瘤生长。它强调节律化疗的机制及其与纳米技术的结合。此外，它还探讨了肿瘤进展和当前的化疗方法。概述了与纳米节律化疗相关的挑战，为这一充满活力的领域的前景铺平了道路。版权所有 © 2024。由 Elsevier B.V. 出版。

Current methods of cancer therapy have demonstrated enormous potential in tumor inhibition. However, a high dosage regimen of chemotherapy results in various complications which affect the normal body cells. Tumor cells also develop resistance against the prescribed drugs in the whole treatment regimen increasing the risk of cancer relapse. Metronomic chemotherapy is a modern treatment method that involves administering drugs at low doses continuously, allowing the drug sufficient time to take its effect. This method ensures that the toxicity of the drugs is to a minimum in comparison to conventional chemotherapy. Nanoparticles have shown efficacy in delivering drugs to the tumor cells in various cancer therapies. Combining nanoparticles with metronomic chemotherapy can yield better treatment results. This combination stimulates the immune system, improving cancer cells recognition by immune cells. Evidence from clinical and pre-clinical trials supports the use of metronomic delivery for drug-loaded nanoparticles. This review focuses on the functionalization of nanoparticles for improved drug delivery and inhibition of tumor growth. It emphasizes the mechanisms of metronomic chemotherapy and its conjunction with nanotechnology. Additionally, it explores tumor progression and the current methods of chemotherapy. The challenges associated with nano-based metronomic chemotherapy are outlined, paving the way for prospects in this dynamic field.Copyright © 2024. Published by Elsevier B.V.