用于治疗溃疡性结肠炎（UC）的水凝胶药物递送系统（DDS）引起了人们的关注。然而，缺乏总结其有效性的荟萃分析。因此，本研究旨在对水凝胶 DDS 与免费给药的临床前证据进行荟萃分析。根据水凝胶材料（多糖与非多糖）和水凝胶 DDS 的给药途径（直肠与口服）进行亚组分析。结果指标包括结肠长度、组织学评分、肿瘤坏死因子-α（TNF-α）、闭锁带蛋白1（ZO-1）和曲线下面积（AUC）。结果证实，与游离药物组相比，水凝胶 DDS 对 UC 的治疗效果增强。值得注意的是，多糖和非多糖材料之间没有发现显着差异，但口服给药在 TNF-α 和 AUC 方面表现更佳。总之，口服水凝胶DDS可以作为口服结肠靶向DDS中潜在的优良剂型，并且在结肠水凝胶递送系统的设计中，多糖与其他材料相比并没有显示出优势。版权所有©2024。由Elsevier B.V.出版。

Hydrogel drug delivery systems (DDSs) for treating ulcerative colitis (UC) have garnered attention. However, there is a lack of meta-analysis summarizing their effectiveness. Therefore, this study aimed to conduct a meta-analysis of pre-clinical evidence comparing hydrogel DDSs with free drug administration. Subgroup analyses were performed based on hydrogel materials (polysaccharide versus non-polysaccharide) and administration routes of the hydrogel DDSs (rectal versus oral). The outcome indicators included colon length, histological scores, tumor necrosis factor-α (TNF-α), zonula occludens protein 1(ZO-1), and area under the curve (AUC). The results confirmed the therapeutic enhancement of the hydrogel DDSs for UC compared with the free drug group. Notably, no significant differences were found between polysaccharide and non-polysaccharide materials, however, oral administration was found superior regarding TNF-α and AUC. In conclusion, oral hydrogel DDSs can serve as potential excellent dosage forms in oral colon -targeting DDSs, and in the design of colon hydrogel delivery systems, polysaccharides do not show advantages compared with other materials.Copyright © 2024. Published by Elsevier B.V.