近年来，由于治疗发展的重大突破，癌症患者的预期寿命得到了延长。然而，这也暴露了癌症幸存者心血管疾病发病率的增加，部分原因是癌症治疗相关的心血管毒性。非编码 RNA (ncRNA) 由于其对基因表达的影响而受到广泛关注。 NcRNA 包括 microRNA、长 ncRNA 和环状 RNA，是非蛋白质编码转录本，参与多种生物过程的调节，从而塑造细胞身份和行为。它们还与疾病的发展有关，包括心血管疾病、癌症以及最近的癌症治疗相关的心脏毒性。这篇综述概述了癌症治疗相关心脏毒性的主要特征、对 ncRNA 在这些过程中的作用的了解以及如何利用 ncRNA 作为心脏保护的治疗靶点。© 2024 作者。约翰·威利出版的《英国药理学杂志》

Life expectancy in cancer patients has been extended in recent years, thanks to major breakthroughs in therapeutic developments. However, this also unmasked an increased incidence of cardiovascular diseases in cancer survivors, which is in part attributable to cancer therapy-related cardiovascular toxicity. Non-coding RNAs (ncRNAs) have received much appreciation due to their impact on gene expression. NcRNAs, which include microRNAs, long ncRNAs and circular RNAs, are non-protein-coding transcripts that are involved in the regulation of various biological processes, hence shaping cell identity and behaviour. They have also been implicated in disease development, including cardiovascular diseases, cancer and, more recently, cancer therapy-associated cardiotoxicity. This review outlines key features of cancer therapy-associated cardiotoxicity, what is known about the roles of ncRNAs in these processes and how ncRNAs could be exploited as therapeutic targets for cardioprotection.© 2024 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.