室外空气污染和颗粒物 (PM) 被列为第一类人类肺癌致癌物。污染物与血液系统癌症之间的关联是有启发性的，但这些癌症在病因学上具有异质性，并且缺乏亚型检查。美国癌症协会癌症预防研究-II 营养队列被用来检查室外空气污染物与成人血液系统癌症之间的关联。人口普查块组级别的颗粒物（PM2.5、PM10、PM10-2.5）、二氧化氮（NO2）、臭氧（O3）、二氧化硫（SO2）和一氧化碳（CO）的年度预测分配有住宅地址。评估了随时间变化的污染物和血液亚型之间的风险比 (HR) 和 95% 置信区间 (CI)。 1992 年至 2017 年，在 108,002 名参与者中，发现了 2659 例血液癌症。较高的 PM10-2.5 浓度与套细胞淋巴瘤相关（HR 每 4.1μg/m3=≥1.43，95% CI 1.08-1.90）。 NO2 与霍奇金淋巴瘤（每 7.2 ppb = 1.39；95% CI 1.01-1.92）和边缘区淋巴瘤（每 7.2 ppb = 1.30；95% CI 1.01-1.67）相关。 CO 与边缘区淋巴瘤（每 0.21 ppm = 1.30；95% CI 1.04-1.62）和 T 细胞淋巴瘤（每 0.21 ppm = 1.27；95% CI 1.00-1.61）淋巴瘤相关。 空气污染物对血液系统癌症的作用由于子类型异质性，之前可能被低估。© 2024。作者。

Outdoor air pollution and particulate matter (PM) are classified as Group 1 human carcinogens for lung cancer. Pollutant associations with haematologic cancers are suggestive, but these cancers are aetiologically heterogeneous and sub-type examinations are lacking.The American Cancer Society Cancer Prevention Study-II Nutrition Cohort was used to examine associations of outdoor air pollutants with adult haematologic cancers. Census block group level annual predictions of particulate matter (PM2.5, PM10, PM10-2.5), nitrogen dioxide (NO2), ozone (O3), sulfur dioxide (SO2), and carbon monoxide (CO) were assigned with residential addresses. Hazard ratios (HR) and 95% confidence intervals (CI) between time-varying pollutants and haematologic subtypes were estimated.Among 108,002 participants, 2659 incident haematologic cancers were identified from 1992-2017. Higher PM10-2.5 concentrations were associated with mantle cell lymphoma (HR per 4.1 μg/m3 = 1.43, 95% CI 1.08-1.90). NO2 was associated with Hodgkin lymphoma (HR per 7.2 ppb = 1.39; 95% CI 1.01-1.92) and marginal zone lymphoma (HR per 7.2 ppb = 1.30; 95% CI 1.01-1.67). CO was associated with marginal zone (HR per 0.21 ppm = 1.30; 95% CI 1.04-1.62) and T-cell (HR per 0.21 ppm = 1.27; 95% CI 1.00-1.61) lymphomas.The role of air pollutants on haematologic cancers may have been underestimated previously because of sub-type heterogeneity.© 2024. The Author(s).