线粒体呼吸复合物发挥着至关重要的功能。因此，功能障碍或变化与许多不同的疾病密切相关，其中包括癌症。线粒体复合物 III 的表观遗传、进化和代谢效应是我们综述的主要关注点。提供了关于柚皮素 (NAR) 作为一种有趣的类黄酮植物化学物质在癌症治疗中的重要作用的新见解。 NAR 是一种重要的植物化学物质，属于黄烷酮多酚类的成员，主要存在于柑橘类水果（例如葡萄柚）以及其他水果和蔬菜（例如西红柿和樱桃）以及由草药制成的食品中。现有证据表明，NAR 作为一种草药，具有显着的药理特性和抗癌作用。 NAR 通过多种机制，包括诱导细胞凋亡、细胞周期停滞、限制血管生成和调节多种信号通路，预防癌症的生长。然而，NAR 的疏水性和晶体结构是其不稳定、有限的口服生物利用度和水溶性的主要原因。此外，在酸性环境中没有靶向性并且分解率很高。这些缺点都阻碍了其高效医疗应用。通过将 NAR 负载到壳聚糖纳米粒子上来改进将 NAR 靶向线粒体复合物 II 是一种很有前景的策略。© 2024。作者。

Mitochondrial respiration complexes play a crucial function. As a result, dysfunction or change is intimately associated with many different diseases, among them cancer. The epigenetic, evolutionary, and metabolic effects of mitochondrial complex IΙ are the primary concerns of our review. Provides novel insight into the vital role of naringenin (NAR) as an intriguing flavonoid phytochemical in cancer treatment. NAR is a significant phytochemical that is a member of the flavanone group of polyphenols and is mostly present in citrus fruits, such as grapefruits, as well as other fruits and vegetables, like tomatoes and cherries, as well as foods produced from medicinal herbs. The evidence that is now available indicates that NAR, an herbal remedy, has significant pharmacological qualities and anti-cancer effects. Through a variety of mechanisms, including the induction of apoptosis, cell cycle arrest, restriction of angiogenesis, and modulation of several signaling pathways, NAR prevents the growth of cancer. However, the hydrophobic and crystalline structure of NAR is primarily responsible for its instability, limited oral bioavailability, and water solubility. Furthermore, there is no targeting and a high rate of breakdown in an acidic environment. These shortcomings are barriers to its efficient medical application. Improvement targeting NAR to mitochondrial complex ΙΙ by loading it on chitosan nanoparticles is a promising strategy.© 2024. The Author(s).