痴呆症包括一系列以认知能力下降和功能障碍为特征的神经退行性疾病。可靠的生物标志物的鉴定对于准确诊断和深入了解疾病的机制至关重要。本研究旨在研究与脑源性神经营养因子 (BDNF)、催产素、神经元 Pentraxin-1 (NPTX1)、触发相关的血浆生物标志物谱阿尔茨海默病 (AD)、路易体痴呆 (DLB)、额颞叶痴呆中骨髓细胞 2 (TREM2)、肿瘤坏死因子-α (TNF-α)、白介素-1 (IL-1) 和催乳素上表达的受体对从门诊单位招募的 23 名 AD、28 名 DLB、15 名 FTD 患者和 22 名健康对照者的上述生物标志物的血清水平进行了分析。诊断评估遵循既定标准，并进行标准化临床测试。收集血样并使用ELISA和电化学发光免疫分析方法进行分析。血清BDNF和催产素水平在各组之间没有显着差异。 NPTX1、TREM2、TNF-α 和 IL-1 水平在痴呆组之间也没有显示出显着差异。然而，催乳素水平表现出不同的模式，与对照组相比，男性 DLB 患者的催乳素水平较低，而女性 AD 患者的催乳素水平较高。研究结果表明痴呆病理生理学中潜在的共同机制，并强调探索神经内分泌反应的重要性，特别是在 AD 和 DLB 中。然而，需要进一步的研究来阐明这些生物标志物在痴呆症诊断和疾病进展中的作用。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Dementia encompasses a range of neurodegenerative disorders characterized by cognitive decline and functional impairment. The identification of reliable biomarkers is essential for accurate diagnosis and gaining insights into the mechanisms underlying diseases.This study aimed to investigate the plasma biomarker profiles associated with Brain- Derived Neurotrophic Factor (BDNF), Oxytocin, Neuronal Pentraxin-1 (NPTX1), Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin- 1 (IL-1), and Prolactin in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementias (FTD), and healthy controls.Serum levels of the aforementioned biomarkers were analyzed in 23 AD, 28 DLB, 15 FTD patients recruited from outpatient units, and 22 healthy controls. Diagnostic evaluations followed established criteria, and standardized clinical tests were conducted. Blood samples were collected and analyzed using ELISA and electrochemiluminescence immunoassay methods.Serum BDNF and oxytocin levels did not significantly differ across groups. NPTX1, TREM2, TNF-alpha, and IL-1 levels also did not show significant differences among dementia groups. However, prolactin levels exhibited distinct patterns, with lower levels in male DLB patients and higher levels in female AD patients compared to controls.The study findings suggest potential shared mechanisms in dementia pathophysiology and highlight the importance of exploring neuroendocrine responses, particularly in AD and DLB. However, further research is warranted to elucidate the role of these biomarkers in dementia diagnosis and disease progression.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.