水的生物物理学已经争论了一个多世纪。尽管其重要性仍然被低估，但近年来出现了重大突破。记录了蛋白质凝结对水可用性控制的影响，出现了关于水运输蛋白质的新发现，并且破译了水分子重新排列以最大限度地减少界面自由能的方式，从而影响膜热力学。深海海洋生物学领域的知识不断取得进展，强调了高静水压力和/或温度对极端环境中蛋白质和配体之间相互作用以及膜结构适应的未知影响。本文还讨论了渗透调节剂在应激条件下蛋白质稳定性控制中与鱼卵水合/浮力相关的作用。细胞内水运动的复杂性得到了更新，所有这些发现使我们能够更好地了解它们对许多细胞过程的影响。水流和离子传输产生的渗透梯度共同产生细胞迁移驱动力的方式也与海洋生物学和癌症研究相关。其他共同点涉及细胞和组织肿瘤转化或胚胎发育过程中水的动态变化。这可以改善成像技术、早期癌症诊断以及对许多海洋物种浮力的分子和生理基础的理解。版权所有 © 2024 Pouliquen。

The biophysics of water, has been debated over more than a century. Although its importance is still underestimated, significant breakthroughs occurred in recent years. The influence of protein condensation on water availability control was documented, new findings on water-transport proteins emerged, and the way water molecules rearrange to minimize free energy at interfaces was deciphered, influencing membrane thermodynamics. The state of knowledge continued to progress in the field of deep-sea marine biology, highlighting unknown effects of high hydrostatic pressure and/or temperature on interactions between proteins and ligands in extreme environments, and membrane structure adaptations. The role of osmolytes in protein stability control under stress is also discussed here in relation to fish egg hydration/buoyancy. The complexity of water movements within the cell is updated, all these findings leading to a better view of their impact on many cellular processes. The way water flow and osmotic gradients generated by ion transport work together to produce the driving force behind cell migration is also relevant to both marine biology and cancer research. Additional common points concern water dynamic changes during the neoplastic transformation of cells and tissues, or embryo development. This could improve imaging techniques, early cancer diagnosis, and understanding of the molecular and physiological basis of buoyancy for many marine species.Copyright © 2024 Pouliquen.