肠道菌群是影响宿主健康的重要因素。随着肠道菌群作用机制的进一步研究，肠道菌群与表观遗传学之间联系的研究取得了重大进展。本研究通过文献计量学可视化肠道微生物群和表观遗传学之间的知识体系和研究重点。在 Web of Science 核心合集 (WoSCC) 数据库中搜索了与肠道微生物群和表观遗传学相关的出版物。使用 Vosviewer 1.6.17 和 CiteSpace 6.1.R2 进行文献计量分析。WoSCC 收录了来自 71 个国家的 460 篇文章。自 2011 年以来，关于肠道微生物群和表观遗传学的出版物数量逐年增加。美国、中国人民和意大利是该领域研究的中心。主要研究机构有加州大学系统、哈佛大学、伦敦大学。 Li，X，Yu，Q，Zhang，S X 是该研究领域的顶级作者。我们发现当前的研究热点和前沿包括短链脂肪酸（SCFA）在肠道菌群和表观遗传学机制中发挥重要作用，肠道菌群和表观遗传学在宿主肥胖、饮食和代谢中发挥重要作用。肠道微生物群和表观遗传学与结直肠癌、乳腺癌和炎症性肠病密切相关。同时，我们发现肠道微生物群通过肠-脑轴调节表观遗传学，并对精神疾病产生影响。因此，益生菌可以调节肠道菌群，改善生活方式，减少疾病的发生和发展。这是首次对肠道菌群和表观遗传学研究领域的趋势和发展进行全面、深入的文献计量研究。这项研究有助于指导学者在当前研究领域的研究方向。版权所有 © 2024 田和陈。

Gut microbiota is an important factor affecting host health. With the further study of the mechanism of gut microbiota, significant progress has been made in the study of the link between gut microbiota and epigenetics. This study visualizes the body of knowledge and research priorities between the gut microbiota and epigenetics through bibliometrics.Publications related to gut microbiota and epigenetics were searched in the Web of Science Core Collection (WoSCC) database. Vosviewer 1.6.17 and CiteSpace 6.1.R2 were used for bibliometric analysis.WoSCC includes 460 articles from 71 countries. The number of publications on gut microbiota and epigenetics has increased each year since 2011. The USA, PEOPLES R CHINA, and ITALY are at the center of this field of research. The University of California System, Harvard University, and the University of London are the main research institutions. Li, X, Yu, Q, Zhang, S X are the top authors in this research field. We found that current research hotspots and frontiers include short-chain fatty acids (SCFA) play an important role in gut microbiota and epigenetic mechanisms, gut microbiota and epigenetics play an important role in host obesity, diet, and metabolism. Gut microbiota and epigenetics are closely related to colorectal cancer, breast cancer, and inflammatory bowel disease. At the same time, we found that gut microbiota regulates epigenetics through the gut-brain axis and has an impact on psychiatric diseases. Therefore, probiotics can regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases.This is the first comprehensive and in-depth bibliometric study of trends and developments in the field of gut microbiota and epigenetics research. This study helps to guide the direction of research scholars in their current field of study.Copyright © 2024 Tian and Chen.