多项研究表明肠道微生物群与淋巴瘤的发展之间可能存在联系，但这种关系的确切性质仍不清楚。本研究旨在探讨肠道微生物群与淋巴瘤之间是否存在因果关系。采用双向双样本孟德尔随机化（MR）方法来研究肠道微生物群与各种淋巴瘤亚型之间的潜在因果关系。 MR 分析采用的主要方法是逆方差加权 (IVW)，并辅以其他方法，包括 MR-Egger、加权中位数和加权众数方法。进行Cochrane Q检验、MR-PRESSO全局检验和MR-Egger截距检验来评估多效性和异质性。此外，还进行了反向 MR 分析，以探索潜在的反向因果效应。主要 MR 分析确定了肠道微生物群遗传倾向与不同淋巴瘤亚型之间的 36 种因果关系。 MR-PRESSO 测试和 MR-Egger 回归均未检测到任何多效性，并且 Cochran 的 Q 测试表明没有显着的异质性。我们的 MR 分析揭示了肠道微生物群与淋巴瘤之间的实质性因果关系，为淋巴瘤预防和管理微生物群提供了新的见解。版权所有 © 2024 梁、刘、王、薛。

Multiple studies have suggested a possible connection between the gut microbiota and the development of lymphoma, though the exact nature of this relationship remains unclear. This study aimed to explore whether a causal association exists between gut microbiota and lymphoma.A bidirectional two-sample Mendelian randomization (MR) approach was conducted to investigate potential causal effects between gut microbiota and various lymphoma subtypes. The primary method employed for MR analysis was inverse variance weighted (IVW), supplemented by additional methods including MR-Egger, weighted median, and weighted mode approaches. The Cochrane Q test, MR-PRESSO global test and MR-Egger intercept test were performed to assess pleiotropy and heterogeneity. Furthermore, a reverse MR analysis was performed to explore potential reverse causal effect.The primary MR analysis identified 36 causal relationships between genetic liabilities in gut microbiota and different lymphoma subtypes. Neither the MR-PRESSO test nor the MR-Egger regression detected any pleiotropy, and Cochran's Q test indicated no significant heterogeneity.Our MR analysis revealed substantial causal associations between gut microbiota and lymphoma, offering new insights into lymphoma prevention and management microbiota.Copyright © 2024 Liang, Liu, Wang and Xue.