性功能障碍是许多成人发病的癌症治疗的一个重要并发症。然而，对于成年儿童癌症幸存者（CCS）的性功能障碍知之甚少。研究因排除特定癌症（例如中枢神经系统 [CNS] 肿瘤）和缺乏经过验证的措施而受到限制，这使得很难了解 CCS 性功能障碍的性质和患病率。总共 249 名成人 CCS （年龄 18-65 岁）参加了一项前瞻性队列研究 Project REACH，并完成了身心健康（包括性功能障碍）的测量。女性性功能指数 6 得分≤19 或国际勃起功能指数 5 得分≤21 的参与者被归类为患有性功能障碍。分析检查了性功能障碍与人口、疾病、治疗和健康变量之间的关系。共有 78 名参与者 (32%) 经历了临床上显着的性功能障碍。在单变量分析中，性功能障碍与中枢神经系统肿瘤诊断（比值比 [OR]，2.56）和手术（OR，1.96）以及疲劳（OR，3.00）、睡眠不佳（OR，2.84）等健康变量显着相关。 ）、疼痛（OR，2.04）、抑郁（OR，2.64）、身体健康状况不佳（OR，2.45）和心理健康状况不佳（OR，2.21）。调整后的分析发现，中枢神经系统肿瘤诊断 (p = .001) 和健康变量 (p = .025) 对 CCS 的性功能障碍有显着影响。大约三分之一的成人 CCS 报告有临床显着的性功能障碍，这强调了重要的筛查和治疗需求。然而，由于现有措施是针对成人癌症幸存者制定的，因此有必要研究专门针对成人 CCS 制定性健康措施，以更好地确定这一弱势群体的性健康问题。© 2024 美国癌症协会。

Sexual dysfunction is a significant complication of treatment for many adult-onset cancers. However, comparatively less is known about sexual dysfunction in adult childhood cancer survivors (CCSs). Research has been limited by the exclusion of specific cancers (e.g., central nervous system [CNS] tumors) and the lack of validated measures, which makes it difficult to understand the nature and prevalence of sexual dysfunction in CCSs.A total of 249 adult CCSs (aged 18-65 years) enrolled in Project REACH, a prospective cohort study, and completed measures of physical and mental health, including sexual dysfunction. Participants scoring ≤19 on the Female Sexual Function Index 6 or ≤21 on the International Index of Erectile Function 5 were classified as experiencing sexual dysfunction. Analyses examined the relationships between sexual dysfunction and demographic, disease, treatment, and health variables.A total of 78 participants (32%) experienced clinically significant sexual dysfunction. In univariate analysis, sexual dysfunction was significantly associated with CNS tumor diagnosis (odds ratio [OR], 2.56) and surgery (OR, 1.96) as well as with health variables such as fatigue (OR, 3.00), poor sleep (OR, 2.84), pain (OR, 2.04), depression (OR, 2.64), poor physical health (OR, 2.45), and poor mental health (OR, 2.21). Adjusted analyses found that CNS tumor diagnosis (p = .001) and health variables (p = .025) contribute significantly to sexual dysfunction in CCSs.Approximately one third of adult CCSs report clinically significant sexual dysfunction, which underscores a significant screening and treatment need. However, because available measures were developed for survivors of adult cancers, research to create a sexual health measure specifically for adult CCSs is necessary to better identify the sexual health concerns of this vulnerable population.© 2024 American Cancer Society.