中心体异常对癌细胞增殖的影响早在 1914 年就已被认识到（Boveri, Zur Frage der Entstehung maligner Tumoren. Jena: G. Fisher, 1914），但直到最近才开始对分子水平的积极研究，直到它变得完全明显。中心体可以作为新的癌症疗法的目标。虽然中心体因其在间期和有丝分裂中作为 MTOC（微管组织中心）的微管组织能力而闻名，但现在中心体因其各种不同的功能而闻名，其中一些功能与微管组织和后续活动（例如细胞分裂、迁移、细胞形状的维持和由运动蛋白驱动的囊泡运输，而其他功能包括在细胞周期调节、代谢活动、信号转导、蛋白水解活性等方面的重要作用，以及其他一些功能，目前正在对其在疾病和疾病中的作用进行深入研究。 (综述见 Schatten 和 Sun, Histochem Cell Biol 150:303-325, 2018;Schatten, Adv Anat Embryol Cell Biol 235:43-50, 2022a;Schatten, Adv Anat Embryol Cell Biol 235:17-35, 2022b)。癌细胞中心体与非癌细胞中心体的不同之处在于表现出特定的异常，包括磷酸化异常、特定中心体蛋白的过度表达、中心粒和中心体重复的异常、在非整倍性和基因组不稳定性中发挥作用的多极纺锤体的形成以及其他一些异常。本综述中强调了卵巢癌。与其他癌症一样，卵巢癌细胞中心体表现出复杂的异常，部分原因是由于个体癌细胞的不同病因导致癌组织中细胞的异质性，本章将更详细地讨论这一点。鉴于中心体在癌细胞增殖中的关键作用，目前正在进行多项研究，以中心体为目标进行治疗干预，以抑制异常癌细胞增殖并控制肿瘤进展。本章将讨论在卵巢癌中观察到的特定中心体异常，重点是针对卵巢癌特异性疗法的此类异常。© 2024。Springer Nature Switzerland AG。

The impact of centrosome abnormalities on cancer cell proliferation has been recognized as early as 1914 (Boveri, Zur Frage der Entstehung maligner Tumoren. Jena: G. Fisher, 1914), but vigorous research on molecular levels has only recently started when it became fully apparent that centrosomes can be targeted for new cancer therapies. While best known for their microtubule-organizing capabilities as MTOC (microtubule organizing center) in interphase and mitosis, centrosomes are now further well known for a variety of different functions, some of which are related to microtubule organization and consequential activities such as cell division, migration, maintenance of cell shape, and vesicle transport powered by motor proteins, while other functions include essential roles in cell cycle regulation, metabolic activities, signal transduction, proteolytic activity, and several others that are now heavily being investigated for their role in diseases and disorders (reviewed in Schatten and Sun, Histochem Cell Biol 150:303-325, 2018; Schatten, Adv Anat Embryol Cell Biol 235:43-50, 2022a; Schatten, Adv Anat Embryol Cell Biol 235:17-35, 2022b).Cancer cell centrosomes differ from centrosomes in noncancer cells in displaying specific abnormalities that include phosphorylation abnormalities, overexpression of specific centrosomal proteins, abnormalities in centriole and centrosome duplication, formation of multipolar spindles that play a role in aneuploidy and genomic instability, and several others that are highlighted in the present review on ovarian cancer. Ovarian cancer cell centrosomes, like those in other cancers, display complex abnormalities that in part are based on the heterogeneity of cells in the cancer tissues resulting from different etiologies of individual cancer cells that will be discussed in more detail in this chapter.Because of the critical role of centrosomes in cancer cell proliferation, several lines of research are being pursued to target centrosomes for therapeutic intervention to inhibit abnormal cancer cell proliferation and control tumor progression. Specific centrosome abnormalities observed in ovarian cancer will be addressed in this chapter with a focus on targeting such aberrations for ovarian cancer-specific therapies.© 2024. Springer Nature Switzerland AG.