由于缺乏识别早期疾病的筛查方法，卵巢癌是女性癌症死亡的第五大原因。因此，预防和早期疾病检测研究是重中之重，围绕着更好地了解疾病进展的重要致病机制的关键机会窗口。微生物调节人类的分子相互作用，从而影响健康和疾病状态，包括卵巢癌。虽然在癌症研究中对触发免疫炎症轴的传染性微生物入侵的机制进行了深入研究，但促进非传染性健康微生物向致病生物扩张转变的复杂相互作用却知之甚少。由于传统研究重点关注感染性病原体对卵巢癌发生和进展的影响，非感染性微生物的影响已引起科学关注。本章的目的是总结关于微生物群在上皮性卵巢癌整个疾病过程中的作用的现有证据。© 2024。Springer Nature Switzerland AG。

Ovarian cancer is the fifth-leading cause of cancer deaths among women due to the absence of available screening methods to identify early disease. Thus, prevention and early disease detection investigations are of high priority, surrounding a critical window of opportunity to better understand important pathogenic mechanisms of disease progression. Microorganisms modulate molecular interactions in humans that can influence states of health and disease, including ovarian cancer. While the mechanisms of infectious microbial invasion that trigger the immune-inflammatory axis are well studied in cancer research, the complex interactions that promote the transition of noninfectious healthy microbes to pathobiont expansion are less understood. As traditional research has focused on the influences of infectious pathogens on ovarian cancer development and progression, the impact of noninfectious microbes has gained scientific attention. The objective of this chapter is to summarize current evidence on the role of microbiota in epithelial ovarian cancer throughout disease.© 2024. Springer Nature Switzerland AG.