磷脂酰肌醇 5-磷酸与 Hippo 通路之间的联系可预防癌症中的上皮间质转化。
A connection between phosphatidylinositol 5-phosphate and the Hippo pathway to prevent epithelial-mesenchymal transition in cancer.
发表日期：2024 May 28
作者：
Emilio Hirsch, Emanuele Fantastico, Lorenzo Prever, Federico Gulluni
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
Hippo 通路阻断转录共激活因子 YAP 介导的癌症中的上皮间质转化和转移。在本期《科学信号》中，Palamiuc 等人。证明磷脂酰肌醇 5-磷酸 (PI5P) 增强 Hippo 通路激活，同时 Hippo 通路通过抑制 PI5P 转化为 PIP2 启动正反馈循环。
The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of Science Signaling, Palamiuc et al. demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP2.