采用先前报道的方法，通过缩合反应合成了四种 Pt(II) 双(吡咯-亚胺)席夫碱螯合物 (1-4)，并得到了 2,2'-{propane-1,3-diylbis获得[次氮基(E)亚甲基]}双(吡咯-1-氨基)铂(II)(1)。 Pt(II) 配合物 1-4 表现出磷光，在厌氧溶剂中或与人血清白蛋白 (HSA) 结合时发光增加。其中一种复合物与 HSA 结合时，量子产率增加了 15.6 倍，可用于检测低至 5 nM 的 HSA 浓度。 Pt(II) 复合物 1-3 作为 MCF-7 乳腺癌细胞中的潜在治疗诊断剂进行了研究，但只有复合物 3 在紫外光（λ355nm 激发）照射时表现出细胞毒性。有趣的是，复合物1的细胞毒性对紫外光照射没有反应。这表明只有复合物 3 可以被视为潜在的光敏剂。版权所有 © 2024。由 Elsevier Inc. 出版。

Four Pt(II) bis(pyrrole-imine) Schiff base chelates (1-4) were synthesised by previously reported methods, through a condensation reaction, and the novel crystal structure of 2,2'-{propane-1,3-diylbis[nitrilo(E)methylylidene]}bis(pyrrol-1-ido)platinum(II) (1) was obtained. Pt(II) complexes 1-4 exhibited phosphorescence, with increased luminescence in anaerobic solvents or when bound to human serum albumin (HSA). One of the complexes shows a 15.6-fold increase in quantum yield when bound to HSA and could be used to detect HSA concentrations as low as 5 nM. Pt(II) complexes 1-3 was investigated as potential theranostic agents in MCF-7 breast cancer cells, but only complex 3 exhibited cytotoxicity when irradiated with UV light (λ355nmExcitation). Interestingly, the cytotoxicity of complex 1 was unresponsive to UV light irradiation. This indicates that only complex 3 can be considered a potential photosensitising agent.Copyright © 2024. Published by Elsevier Inc.