血液系统恶性肿瘤患者是在性腺毒性肿瘤治疗前转诊进行生育力保留的最常见群体之一。本系统评价和荟萃分析的目的是评估与健康对照相比，血液癌对卵巢储备和卵巢刺激反应的影响。最终的定量分析中总共纳入了八项观察性研究。尽管血液系统恶性肿瘤患者年龄较小（平均差 -4.17，95% CI -6.20 至 -2.14；P < 0.0001），但与对照组相比，其血清抗苗勒管激素水平较低（MD -1.04，95% CI - 1.80至-0.29；P=0.007)。重组 FSH 总剂量略高（MD 632.32，95% CI -187.60 至 1452.24；P=0.13），雌二醇血清峰值水平显着降低（MD -994.05，95% CI -1962.09 至 -26.02；P=0.04）研究组与健康对照组进行比较。两组获得的卵母细胞数量相似（MD 0.20，95% CI -0.80 至 1.20；P=0.69）。总之，尽管与健康对照相比年龄较小，但血液恶性肿瘤可能对卵巢功能产生不利影响，表现为 AMH 血清水平降低。这种影响可以通过应用相关 IVF 方案和刺激剂量来克服，以获得足够的卵母细胞产量。版权所有 © 2024 Reproductive Healthcare Ltd. 由 Elsevier Ltd 出版。保留所有权利。

Patients with haematologic malignancies represent one of the most common groups referred for fertility preservation before gonadotoxic oncological treatment. The aim of this systematic review and meta-analysis was to evaluate the effect of haematologic cancer on ovarian reserve and response to ovarian stimulation compared with healthy controls. A total of eight observative studies were included in the final quantitative analysis. Despite a younger age (mean difference -4.17, 95% CI -6.20 to -2.14; P < 0.0001), patients with haematologic malignancy had lower serum anti-Müllerian hormone levels compared with the control group (MD -1.04, 95% CI -1.80 to -0.29; P = 0.007). The marginally higher total recombinant FSH dose (MD 632.32, 95% CI -187.60 to 1452.24; P = 0.13) and significantly lower peak oestradiol serum level (MD -994.05, 95% CI -1962.09 to -26.02; P = 0.04) were demonstrated in the study group compared with the healthy controls. A similar number of retrieved oocytes were achieved in both groups (MD 0.20, 95% CI -0.80 to 1.20; P = 0.69). In conclusion, haematologic malignancies may detrimentally affect ovarian function manifesting in decreased AMH serum levels despite a younger age compared with healthy controls. This effect can be overcome by the application of relevant IVF protocols and stimulation doses to achieve an adequate oocyte yield.Copyright © 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.