微管靶向剂（MTA）作为抗肿瘤、抗真菌、抗寄生虫和除草剂已表现出显着的功效，在临床、兽医和农化行业中得到应用。微管蛋白和微管结构生物学的最新进展提供了强大的工具，为未来基础和应用生命科学应用的创新小分子 MTA 的合理设计铺平了道路。在这篇小综述中，我们介绍了微管蛋白和微管结构生物学领域的现状、它对 MTA 的发现和合理设计的最新影响，以及未来 MTA 研究的令人兴奋的途径。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Microtubule-targeting agents (MTAs) have demonstrated remarkable efficacy as antitumor, antifungal, antiparasitic, and herbicidal agents, finding applications in the clinical, veterinary, and agrochemical industry. Recent advances in tubulin and microtubule structural biology have provided powerful tools that pave the way for the rational design of innovative small-molecule MTAs for future basic and applied life science applications. In this mini-review, we present the current status of the tubulin and microtubule structural biology field, the recent impact it had on the discovery and rational design of MTAs, and exciting avenues for future MTA research.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.