外泌体对于胶质母细胞瘤（一种侵袭性脑癌）的生长和扩散至关重要。这些微小的囊泡在信号通路的激活和细胞间通讯中发挥着至关重要的作用。它们还可以将蛋白质、脂质和核酸等多种生物分子从供体细胞转移到受体细胞。外泌体可以通过调节免疫细胞的活性来影响免疫反应，它们对于胶质母细胞瘤细胞的生长和转移至关重要。此外，外泌体在治疗过程中会产生耐药性，这是胶质母细胞瘤治疗的主要障碍。通过研究它们，可以改善胶质母细胞瘤的诊断和预后。由于其高生物相容性和无毒性，它们已成为药物输送的有吸引力的选择。开发外泌体作为特定治疗药物的载体可以克服有效治疗胶质母细胞瘤的一些障碍。在这篇综述中，我们探讨了外泌体治疗胶质母细胞瘤的潜力，并展示了如何为此目的对其进行修饰。版权所有 © 2024。由 Elsevier Inc. 出版。

Exosomes are crucial for the growth and spread of glioblastomas, an aggressive form of brain cancer. These tiny vesicles play a crucial role in the activation of signaling pathways and intercellular communication. They can also transfer a variety of biomolecules such as proteins, lipids and nucleic acids from donor to recipient cells. Exosomes can influence the immune response by regulating the activity of immune cells, and they are crucial for the growth and metastasis of glioblastoma cells. In addition, exosomes contribute to drug resistance during treatment, which is a major obstacle in the treatment of glioblastoma. By studying them, the diagnosis and prognosis of glioblastoma can be improved. Due to their high biocompatibility and lack of toxicity, they have become an attractive option for drug delivery. The development of exosomes as carriers of specific therapeutic agents could overcome some of the obstacles to effective treatment of glioblastoma. In this review, we address the potential of exosomes for the treatment of glioblastoma and show how they can be modified for this purpose.Copyright © 2024. Published by Elsevier Inc.