生物分子凝聚物是由液-液相分离（LLPS）形成的无膜细胞区室，代表了生理和致瘤过程的重要机制。最近的研究加深了我们对细胞质或细胞核中形成的这些凝聚物如何调节 Hippo 信号传导（器官发生和肿瘤发生的核心角色）的理解。在此，我们回顾了生理和病理过程中生物分子缩合物在调节 Hippo-yes 相关蛋白（YAP）/转录共激活子与 PDZ 结合基序（TAZ）信号通路中的动态形成和功能的最新研究结果。我们进一步讨论了 YAP 或 TAZ 融合癌蛋白的核凝聚物如何划分关键的转录共激活因子并改变染色质结构以促进致癌程序。最后，我们强调了有关这些发现如何为针对癌症的新疗法铺平道路的关键问题。版权所有 © 2024 Elsevier Ltd。保留所有权利。

Biomolecular condensates, the membraneless cellular compartments formed by liquid-liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes. Recent studies have advanced our understanding of how these condensates formed in the cytoplasm or nucleus regulate Hippo signaling, a central player in organogenesis and tumorigenesis. Here, we review recent findings on the dynamic formation and function of biomolecular condensates in regulating the Hippo-yes-associated protein (YAP)/transcription coactivator with PDZ-binding motif (TAZ) signaling pathway under physiological and pathological processes. We further discuss how the nuclear condensates of YAP- or TAZ-fusion oncoproteins compartmentalize crucial transcriptional co-activators and alter chromatin architecture to promote oncogenic programs. Finally, we highlight key questions regarding how these findings may pave the way for novel therapeutics to target cancer.Copyright © 2024 Elsevier Ltd. All rights reserved.