近年来，多发性骨髓瘤 (MM) 治疗方法取得了巨大发展，患者预后显着改善。随着新的治疗方案的开发，干细胞移植（SCT）仍然是一种重要的方式，可以提供良好的疾病控制并延缓疾病的进展。多年来，美国 SCT 的使用总体有所增加，但仍然存在两个明显的差距，包括总体使用次优和种族差异。我们评估了国家癌症数据库 (NCDB)，以研究哪些社会人口因素可能在特定种族群体中发挥作用，导致不同的 SCT 使用，从而可以开发有针对性的方法来优化所有人的 SCT 使用。在属于非西班牙裔白人 (NHW)、非西班牙裔黑人 (NHB)、西班牙裔、非西班牙裔亚洲人 (NHA) 等相互排斥类别的近 112,000 例病例中，我们发现了某些因素，包括年龄、合并症指数、付款人类型、设施类型（学术与社区）和设施数量与所有种族群体的 SCT 使用统一相关，而性别对于任何群体都不显着。在所研究的不同种族群体中，还有其他几个因素对 SCT 的利用产生不同的影响，包括诊断年份（对于 NHW、NHB 和西班牙裔人来说很重要）、收入水平（对于 NHW 和西班牙裔人来说很重要）、识字水平（对于 NHW 和西班牙裔人来说很重要）。对于 NHW 和 NHB 很重要），以及治疗设施的地理位置（对于 NHW 和 NHA 很重要）。美国整体 SCT 利用率未达到最佳水平，这表明所有人（甚至包括大多数 NHW）可能还有改进的空间，同时我们将继续研究导致传统上服务不足的人群出现差异的因素。这项研究有助于确定可能在每个群体中发挥具体作用的社会人口因素，并为制定有针对性的解决方案铺平道路，从而最大限度地提高资源利用率和影响力。© 2024。作者。

Multiple myeloma (MM) therapeutics have evolved tremendously in recent years, with significant improvement in patient outcomes. As newer treatment options are developed, stem cell transplant (SCT) remains an important modality that provides excellent disease control and delays the progression of disease. Over the years, SCT use has increased overall in the U.S., but two distinct gaps remain, including suboptimal use overall and racial-ethnic disparities. We evaluated the National Cancer Database (NCDB) to study what sociodemographic factors might play a role within a given racial-ethnic group leading to disparate SCT utilization, such that targeted approaches can be developed to optimize SCT use for all. In nearly 112,000 cases belonging to mutually exclusive categories of non-Hispanic Whites (NHW), non-Hispanic Blacks (NHB), Hispanics, non-Hispanic Asians (NHA), and others, we found certain factors including age, comorbidity index, payor type, facility type (academic vs. community) and facility volume to be uniformly associated with SCT use for all the racial-ethnic groups, while gender was not significant for any of the groups. There were several other factors that had a differential impact on SCT utilization among the various race-ethnicity groups studied, including year of diagnosis (significant for NHW, NHB, and Hispanics), income level (significant for NHW and Hispanics), literacy level (significant for NHW and NHB), and geographic location of the treatment facility (significant for NHW and NHA). The suboptimal SCT utilization overall in the U.S. suggests that there may be room for improvement for all, even including the majority NHW, while we continue to work on factors that lead to disparities for the traditionally underserved populations. This study helps identify sociodemographic factors that may play a role specifically in each group and paves the way to devise targeted solutions such that resource utilization and impact can be maximized.© 2024. The Author(s).