乳腺癌是全球女性中最常见的癌症，受到遗传和环境因素的共同影响。最近的研究调查了乳腺癌进展过程中 microRNA (miRNA) 的变化以及环境化学物质对 miRNA 表达的潜在影响。本综述旨在提供乳腺癌中 miRNA 改变的最新概述，并探讨它们与环境化学物质的潜在关联。我们将讨论目前关于乳腺癌失调 miRNA 的知识，包括上调和下调的 miRNA。此外，我们将回顾环境化学物质（例如内分泌干扰化合物、重金属和空气污染物）对 miRNA 表达的影响及其对乳腺癌发展的潜在贡献。本综述旨在通过全面检查 miRNA 的改变及其与环境化学物质的关联，促进我们对乳腺癌中 miRNA 失调的复杂分子机制的理解。这些知识对于开发靶向治疗和预防措施至关重要。此外，识别受环境化学物质影响的特定 miRNA 可以预测个体对乳腺癌的易感性并设计个性化干预策略。版权所有 © 2024 Abolhasanzadeh、Sarabandi、Dehghan、Karamad、Avci、Shademan 和 Nourazarian。

Breast cancer stands as the most prevalent form of cancer among women globally, influenced by a combination of genetic and environmental factors. Recent studies have investigated changes in microRNAs (miRNAs) during breast cancer progression and the potential impact of environmental chemicals on miRNA expression. This review aims to provide an updated overview of miRNA alterations in breast cancer and to explore their potential association with environmental chemicals. We will discuss the current knowledge on dysregulated miRNAs in breast cancer, including both upregulated and downregulated miRNAs. Additionally, we will review the influence of environmental chemicals, such as endocrine-disrupting compounds, heavy metals, and air pollutants, on miRNA expression and their potential contribution to breast cancer development. This review aims to advance our understanding of the complex molecular mechanisms underlying miRNA dysregulation in breast cancer by comprehensively examining miRNA alterations and their association with environmental chemicals. This knowledge is crucial for the development of targeted therapies and preventive measures. Furthermore, identifying specific miRNAs affected by environmental chemicals may allow the prediction of individual susceptibility to breast cancer and the design of personalized intervention strategies.Copyright © 2024 Abolhasanzadeh, Sarabandi, Dehghan, Karamad, Avci, Shademan and Nourazarian.