E2F 转录因子家族在细胞周期进程和细胞增殖的调节中发挥着至关重要的作用。越来越多的证据表明，E2F2 的异常表达或激活是恶性肿瘤中的常见现象。 E2F2已成为各类肿瘤发生和进展的关键参与者。大量研究证实 E2F2 可能有助于增强肿瘤细胞增殖、血管生成和侵袭性。此外，E2F2 通过与一系列辅助因子和下游靶标（包括细胞凋亡和 DNA 修复）结合，对无数细胞过程发挥影响。 E2F2在致癌过程中的失调可能归因于多种机制，其中包括上游调控元件的修饰或表观遗传改变。本综述探讨了 E2F2 在癌症进展中的功能以及针对该致癌途径的既定和新兴治疗策略，同时也为 E2F2 的生物学功能和临床应用的进一步研究提供了坚实的基础。版权所有 © 2024 高，乔，刘、张。

The E2F family of transcription factors plays a crucial role in the regulation of cell cycle progression and cell proliferation. Accumulative evidence indicates that aberrant expression or activation of E2F2 is a common phenomenon in malignances. E2F2 has emerged as a key player in the development and progression of various types of tumors. A wealth of research has substantiated that E2F2 could contribute to the enhancement of tumor cell proliferation, angiogenesis, and invasiveness. Moreover, E2F2 exerts its influence on a myriad of cellular processes by engaging with a spectrum of auxiliary factors and downstream targets, including apoptosis and DNA repair. The dysregulation of E2F2 in the context of carcinogenesis may be attributable to a multitude of mechanisms, which encompass modifications in upstream regulatory elements or epigenetic alterations. This review explores the function of E2F2 in cancer progression and both established and emerging therapeutic strategies aiming at targeting this oncogenic pathway, while also providing a strong basis for further research on the biological function and clinical applications of E2F2.Copyright © 2024 Gao, Qiao, Liu and Zhang.