目前还没有任何理论可以定量描述复杂的肿瘤生态系统。与此同时，癌症免疫疗法被认为是肿瘤学的一场革命，但用于描述肿瘤的方法和用于评估疗效的标准并没有跟上步伐。本研究的目的是建立定量描述肿瘤生态系统的新理论，创新肿瘤表征方法，建立癌症免疫治疗新的疗效评价标准。前期研究采用逆向免疫动力学的方法，即将免疫制动力视为肿瘤生态制动力，将免疫力视为肿瘤生态制动力，将物理学中动量的概念应用于肿瘤生态系统建立一系列肿瘤生态动力学方程。这些方程用于解决复杂肿瘤生态系统的基础和应用问题。建立了一系列肿瘤生态动力学方程。肿瘤生态动量方程及其组成因子可用于区分癌症免疫治疗中的疾病进展、假性进展和超进展。在此基础上，建立调整后的肿瘤动量方程，实现肿瘤活性（包括免疫抑制活性和代谢活性）与肿瘤体积的等价，可用于计算个体疾病缓解率，建立新的疗效评价标准（即RECIST）基于肿瘤生态动力学的实体瘤免疫治疗。同时提出了移动立方与力平方比的概念及其表达式，计算调整后的肿瘤生态动量为达到个体疾病缓解率所需的血液肿瘤生态制动力曲线下面积建立了一种强调肿瘤活性和肿瘤体积的肿瘤生态动力学新理论，以解决复杂的肿瘤生态系统中的一系列基础和应用问题。可以预见，未来将是针对整个肿瘤生态系统的癌症免疫生态治疗时代。Copyright © 2024 Chen.

There is no theory to quantitatively describe the complex tumor ecosystem. At the same time, cancer immunotherapy is considered a revolution in oncology, but the methods used to describe tumors and the criteria used to evaluate efficacy are not keeping pace. The purpose of this study is to establish a new theory for quantitatively describing the tumor ecosystem, innovating the methods of tumor characterization, and establishing new efficacy evaluation criteria for cancer immunotherapy.Based on the mathematization of immune equilibrium theory and the establishment of immunodynamics in a previous study, the method of reverse immunodynamics was used, namely, the immune braking force was regarded as the tumor ecological force and the immune force was regarded as the tumor ecological braking force, and the concept of momentum in physics was applied to the tumor ecosystem to establish a series of tumor ecodynamic equations. These equations were used to solve the fundamental and applied problems of the complex tumor ecosystem.A series of tumor ecodynamic equations were established. The tumor ecological momentum equations and their component factors could be used to distinguish disease progression, pseudoprogression, and hyperprogression in cancer immunotherapy. On this basis, the adjusted tumor momentum equations were established to achieve the equivalence of tumor activity (including immunosuppressive activity and metabolic activity) and tumor volume, which could be used to calculate individual disease remission rate and establish new efficacy evaluation criteria (ieRECIST) for immunotherapy of solid tumor based on tumor ecodynamics. At the same time, the concept of moving cube-to-force square ratio and its expression were proposed to calculate the area under the curve of tumor ecological braking force of blood required to achieve an individual disease remission rate when the adjusted tumor ecological momentum was known.A new theory termed tumor ecodynamics emphasizing both tumor activity and tumor volume is established to solve a series of basic and applied problems in the complex tumor ecosystem. It can be predicted that the future will be the era of cancer immune ecotherapy that targets the entire tumor ecosystem.Copyright © 2024 Chen.